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The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract

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dc.contributor.authorKim, B. J.-
dc.contributor.authorSo, I.-
dc.contributor.authorKim, K. W.-
dc.date.accessioned2010-01-08T08:07:38Z-
dc.date.available2010-01-08T08:07:38Z-
dc.date.issued2006-05-17-
dc.identifier.citationJ Smooth Muscle Res. 2006 Feb;42(1):1-7.en
dc.identifier.issn0916-8737 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16702759-
dc.identifier.urihttps://hdl.handle.net/10371/29031-
dc.description.abstractInterstitial cells of Cajal (ICCs) are a fundamental component of the pacemaker apparatus of the gastrointestinal (GI) tract. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal smooth muscle. The pacemaker current that generates slow waves is initially due to a voltage-independent, Ca(2+)-inhibited, non-selective cationic conductance in ICC. The classical transient receptor potential (TRPC) channel 4 was suggested as a molecular candidate for the nonselective cation channel (NSCC) responsible for the pacemaker activity. We have shown that TRPC4-/- mice display normal slow waves and suggest that TRPC4 might be an essential component of the NSCC activated by muscarinic stimulation. Finally, we suggest that TRPM7 is the molecular candidate for the NSCC responsible for pacemaker activity in ICCs on the basis of electrophysiological, molecular biological, and immunohistochemical experiments.en
dc.language.isoenen
dc.publisherThe Japanese Society of Smooth Muscle Researchen
dc.subjectAnimalsen
dc.subjectBiological Clocks/physiologyen
dc.subjectEnteric Nervous System/*cytologyen
dc.subjectGastrointestinal Tract/*innervationen
dc.subjectMiceen
dc.subjectMyocytes, Smooth Muscle/*cytologyen
dc.subjectTRPC Cation Channels/*physiologyen
dc.titleThe relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tracten
dc.typeArticleen
dc.contributor.AlternativeAuthor김병주-
dc.contributor.AlternativeAuthor서인석-
dc.contributor.AlternativeAuthor김기환-
dc.contributor.AlternativeAuthorKim, Byung Joo-
dc.contributor.AlternativeAuthorSo, Insuk-
dc.contributor.AlternativeAuthorKim, Ki Whan-
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