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Developmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal cord

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dc.contributor.authorPark, Sang Wook-
dc.contributor.authorLim, Ha Seong-
dc.contributor.authorRoh, Eun Jung-
dc.contributor.authorKim, Dong Woon-
dc.contributor.authorJeon, Gye Sun-
dc.contributor.authorCho, Sa Sun-
dc.date.accessioned2010-01-08T08:21:19Z-
dc.date.available2010-01-08T08:21:19Z-
dc.date.issued2006-12-08-
dc.identifier.citationNeurochem Res. 2007 Jan;32(1):11-8. Epub 2006 Dec 6.en
dc.identifier.issn0364-3190 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17151919-
dc.identifier.urihttps://hdl.handle.net/10371/29054-
dc.description.abstractOligodendrocytes develop from precursor cells in the neuroepithelium of the ventral ventricular zone. Oligodendrocytes in the different stages of development are characterized by expression of a number of different marker molecules such as myelin genes, growth factors, and specific antigens. We have previously identified that transferrin binding protein (TfBP), a member of heat shock protein 90 families, is a novel avian ER-associated membrane protein that is specifically localized in oligodendrocytes in adult chicken CNS. In this study we describe the developmental expression of TfBP in the embryonic chick spinal cord. A few, distinct, TfBP+ cells appeared at the lateral margin of the subventricular neuroepithelium of the spinal cord at E7. Thereafter, some TfBP+ cells, exhibited a migrative form of unipolar or bipolar shape occurred around E8 in the mantle layer, midway between the neuroepithelium and the marginal layer of the primitive spinal cord. Thereafter, the TfBP+ cells rapidly increased in number as well as their staining intensity, and overall distribution of TfBP+ cells at E15 was comparable to that of a mature spinal cord. Our observations suggest that TfBP is expressed in the subpopulation of oligodendrocyte lineage in the development and a putative role of TfBP in relation to transferrin and iron trafficking is considered.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAnimalsen
dc.subjectBlotting, Westernen
dc.subjectCell Lineageen
dc.subjectChick Embryoen
dc.subjectImmunohistochemistryen
dc.subjectMicroscopy, Fluorescenceen
dc.subjectOligodendroglia/cytology/immunology/*metabolismen
dc.subjectSpinal Cord/embryologyen
dc.subjectTransferrin-Binding Proteins/*biosynthesisen
dc.subjectGene Expression Regulation, Developmental-
dc.titleDevelopmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal corden
dc.typeArticleen
dc.contributor.AlternativeAuthor박상욱-
dc.contributor.AlternativeAuthor임하승-
dc.contributor.AlternativeAuthor노은정-
dc.contributor.AlternativeAuthor김동운-
dc.contributor.AlternativeAuthor전계선-
dc.contributor.AlternativeAuthor조사선-
dc.identifier.doi10.1007/s11064-006-9216-6-
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