Browse

Surgical treatment of malignant mediastinal neurogenic tumors in children

DC Field Value Language
dc.contributor.authorKang, Chang Hyun-
dc.contributor.authorKim, Young Tae-
dc.contributor.authorJeon, Sang-Hoon-
dc.contributor.authorSung, Sook-Whan-
dc.contributor.authorKim, Joo Hyun-
dc.date.accessioned2010-01-08T08:22:50Z-
dc.date.available2010-01-08T08:22:50Z-
dc.date.issued2007-02-20-
dc.identifier.citationEur J Cardiothorac Surg. 2007 Apr;31(4):725-30. Epub 2007 Feb 16.en
dc.identifier.issn1010-7940 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17306984-
dc.identifier.urihttp://hdl.handle.net/10371/29059-
dc.description.abstractINTRODUCTION: The aim of this study was to identify the role of surgical resection in the treatment of malignant mediastinal neurogenic tumors in children. MATERIALS AND METHODS: Thirty-eight consecutive children, who underwent surgical resection of a malignant mediastinal neurogenic tumor between 1986 and 2004, were included in this study. The tumor cell types were neuroblastoma in 23 patients (60.5%), ganglioneuroblastoma in 14 (36.8%), and malignant neuroepithelioma in 1 (2.6%). Surgery was performed for curative resection in localized tumors and salvage resection of residual mediastinal masses after chemotherapy in stage IV tumors. Of the 16 patients (42.1%) who underwent salvage resection, 14 had neuroblastoma and 2 ganglioneuroblastoma. RESULTS: Mean patient age was 3.4+/-3.0 years (1 month-13 years) and 26 patients (68.4%) were symptomatic at presentation. Adjacent structure invasion was found in eight patients (21.1%), invasion of chest wall in four, heart and vena cava in two, lung in one, and chest wall and lung in one. Complete gross resection was possible in 30 patients (78.9%) and there was no surgical mortality. Surgical morbidity occurred in 10 patients (26.3%) and Horner's syndrome was the most frequent complication (n=7). The 5-year survival was 95.2% for a localized tumor and 52.5% for a stage IV tumor (p=0.004). The significant risk factors of long-term survival were adjacent structure invasion (p=0.002) and a stage IV tumor (p=0.002) by multivariate Cox regression analysis. CONCLUSIONS: Surgical resection of localized malignant mediastinal neurogenic tumor in children showed good long-term survival, and salvage operations after chemotherapy showed acceptable long-term survival.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectGanglioneuroblastoma/mortality/surgeryen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectMediastinal Neoplasms/mortality/*surgeryen
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Metastasisen
dc.subjectNeoplasm Stagingen
dc.subjectNeuroblastoma/mortality/surgeryen
dc.subjectNeuroectodermal Tumors, Primitive, Peripheral/mortality/*surgeryen
dc.subjectPostoperative Complicationsen
dc.subjectPreoperative Care/methodsen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectTreatment Outcomeen
dc.titleSurgical treatment of malignant mediastinal neurogenic tumors in childrenen
dc.typeArticleen
dc.contributor.AlternativeAuthor강창현-
dc.contributor.AlternativeAuthor김영태-
dc.contributor.AlternativeAuthor전상훈-
dc.contributor.AlternativeAuthor성숙환-
dc.contributor.AlternativeAuthor김주현-
dc.identifier.doi10.1016/j.ejcts.2007.01.026-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse