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Clinical results of stereotactic body frame based fractionated radiation therapy for primary or metastatic thoracic tumors

Cited 32 time in Web of Science Cited 35 time in Scopus
Authors
Yoon, Sang Min; Choi, Eun Kyung; Lee, Sang-Wook; Yi, Byong Yong; Ahn, Seung Do; Shin, Seong Soo; Park, Heon Joo; Kim, Su Ssan; Park, Jin-Hong; Song, Si Yeol; Park, Charn Il; Kim, Jong Hoon
Issue Date
2006-11-23
Publisher
Taylor & Francis
Citation
Acta Oncol. 2006;45(8):1108-14.
Keywords
AdolescentAdultAgedAged, 80 and overChildDose FractionationFemaleHumansMaleMiddle AgedPositron-Emission TomographyRadiosurgery/*instrumentationSurvival RateThoracic Neoplasms/*surgeryTreatment Outcome
Abstract
The aim of this study was to evaluate the treatment outcomes of stereotactic body radiation therapy for treating primary or metastatic thoracic tumors using a stereotactic body frame. Between January 1998 and February 2004, 101 lesions from 91 patients with thoracic tumors were prospectively reviewed. A dose of 10-12 Gy per fraction was given three to four times over consecutive days to a total dose of 30-48 Gy (median 40 Gy). The overall response rate was 82%, with 20 (22%) complete responses and 55 (60%) partial responses. The one- and two-year local progression free survival rates were 90% and 81%, respectively. The patients who received 48 Gy showed a better local tumor control than those who received less than 48 Gy (Fisher exact test; p = 0.004). No pulmonary complications greater than a RTOG toxicity criteria grade 2 were observed. The experience of stereotactic body frame based radiation therapy appears to be a safe and promising treatment modality for the local management of primary or metastatic lung tumors. The optimal total dose, fractionation schedule and treatment volume need to be determined after a further follow-up of these results.
ISSN
0284-186X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17118847

http://hdl.handle.net/10371/29072
DOI
https://doi.org/10.1080/02841860600812685
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College of Medicine/School of Medicine (의과대학/대학원)Radiation Oncology (방사선종양학전공)Journal Papers (저널논문_방사선종양학전공)
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