Browse
S-Space
College of Medicine/School of Medicine (의과대학/대학원)
Internal Medicine (내과학전공)
Journal Papers (저널논문_내과학전공)
Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance
- Issue Date
- 2006-10-28
- Publisher
- Oxford University Press
- Citation
- Int Immunol. 2006 Dec;18(12):1771-7. Epub 2006 Oct 26.
- Keywords
- Animals ; Antigens, CD11c/metabolism ; Antigens, CD4/metabolism ; Antigens, CD8/metabolism ; Dendritic Cells/*cytology/transplantation ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Species Specificity ; Graft Survival/physiology ; Islets of Langerhans Transplantation ; Tissue Donors/classification ; Transplantation Tolerance ; Transplantation, Homologous
- Abstract
- Dendritic cells (DCs) are pivotal antigen-presenting cells and serve a unique role in initiating immunity. To test the hypothesis that pre-immunization of recipient with certain DC subsets of donor origin can influence graft outcome, we have studied the effects of immunization with allogeneic CD4(+)CD8(-)CD11c(+) dendritic cell (CD4(+)DC) and CD4(-)CD8(+)CD11c(+) dendritic cell (CD8(+)DC) on the allograft response. Although both immature CD4(+)DC and CD8(+)DC subsets from DBA/2 were able to prime naive allogeneic C57BL/6 (B6) T cells in mixed lymphocyte reaction (MLR), CD8(+)DC exerted more vigorous alloimmune responses than CD4(+)DC did. Also, CD4(+)DC-driven allogeneic T cell response was attenuated more significantly by anti-CD154 mAb than CD8(+)DC-driven response. Consistent with the MLR results, combined pre-treatment with CD4(+)DC, but not CD8(+)DC, plus anti-CD154 mAb produced donor strain-specific long-term graft survival and induced tolerance while treatment with CD8(+)DC plus anti-CD154 mAb created minimal prolongation of allograft survival in a pancreas islet transplant model (DBA/2-->B6). The beneficial effects exerted by CD4(+)DC and anti-CD154 mAb pre-treatment were correlated with T(h)1 to T(h)2 immune deviation and with the amplified donor-specific suppressive capacity by recipient CD4(+)CD25(+) T cells. These findings highlight the capacity of CD4(+)DC to modulate alloimmune responses, and suggest therapeutic approaches for the induction of donor-specific tolerance.
- ISSN
- 0953-8178 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17068105
https://hdl.handle.net/10371/29081
- Files in This Item: There are no files associated with this item.
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.