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Non-myeloablative allogeneic stem cell transplantation for metastatic renal cell carcinoma

Cited 4 time in Web of Science Cited 5 time in Scopus
Authors
Yun, Tak; Lee, Keun-Wook; Song, Eun-Gi; Na, Im-Il; Shin, Hyun-Chun; Yoon, Sung-Soo; Park, Seon-Yang; Kim, Byoung-Kook; Lee, Jung-Hee; Choi, Seong-Jun; Lee, Je-Hwan; Lee, Kyoo-Hyung
Issue Date
2007-05-10
Publisher
Wiley-Blackwell
Citation
Clin Transplant. 2007 May-Jun;21(3):337-43.
Keywords
AdultCarcinoma, Renal Cell/immunology/mortality/*surgeryChimerismDisease ProgressionFemaleGraft vs Host DiseaseHumansImmunotherapyKidney Neoplasms/immunology/mortality/*surgeryMaleMiddle AgedMyeloablative Agonists*Stem Cell TransplantationTransplantation Conditioning
Abstract
Between 1999 and 2004, 11 patients with metastatic renal cell carcinoma (RCC) underwent non-myeloablative stem cell transplantation (NST) with conditioning using fludarabine-based regimens in two institutions of Korea. Among 11 patients, only one patient showed partial response (response rate: 9%), three showed stable disease, and six progressive disease. Three patients developed acute graft-versus-host disease (GVHD), and among them, one developed grade III acute GVHD which caused early death at day 60 after transplantation, and this patient showed partial response at day 30. Six patients developed chronic GVHD, three limited, and three extensive GVHD, respectively. Survival after one yr was 18% in transplanted patients. Median overall survival for entire cohort was 4.3 months. Eight patients died from progressive disease and three (27%) from treatment-related mortality. Only one patient survived 51.2 months after NST with slowly progressive disease. This patient received donor lymphocyte infusion three times after NST and achieved complete donor chimerism. NST does not lead to durable response and prolonged overall survival in the majority of patients with RCC in our series.
ISSN
0902-0063 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17488382

http://hdl.handle.net/10371/29107
DOI
https://doi.org/10.1111/j.1399-0012.2007.00646.x
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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