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Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels

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dc.contributor.authorPark, Won Sun-
dc.contributor.authorSon, Youn Kyoung-
dc.contributor.authorKim, Nari-
dc.contributor.authorKo, Jae-Hong-
dc.contributor.authorKang, Sung Hyun-
dc.contributor.authorWarda, Mohamad-
dc.contributor.authorEarm, Yung E.-
dc.contributor.authorJung, In Duk-
dc.contributor.authorPark, Yeong-Min-
dc.contributor.authorHan, Jin-
dc.date.accessioned2010-01-11T07:04:24Z-
dc.date.available2010-01-11T07:04:24Z-
dc.date.issued2007-05-09-
dc.identifier.citationPflugers Arch. 2007 Sep;454(6):1023-30. Epub 2007 May 8.en
dc.identifier.issn0031-6768 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17486361-
dc.identifier.urihttp://hdl.handle.net/10371/29351-
dc.description.abstractWe examined the effects of acute hypoxia on vascular tone and coronary blood flow (CBF) in rabbit coronary arteries. In the pressurized arterial preparation of small arteries (<100 mum) and the Langendorff-perfused rabbit hearts, hypoxia induced coronary vasodilation and increased CBF in the presence of glibenclamide (K(ATP) channel blocker), Rp-8-Br-PET-cGMPs [cyclic guanosine monophosphate (cGMP)-dependent protein kinase inhibitor, Rp-cGMPs], and methionyl transfer RNA synthetase (MRS) 1334 (adenosine A(3) receptor inhibitor); these increases were inhibited by the inward rectifier K(+) (Kir) channel inhibitor, Ba(2+). These effects were blocked by the adenylyl cyclase inhibitor SQ 22536 and by the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) inhibitors Rp-8-CPT-cAMPs (Rp-cAMPs) and KT 5720. However, cGMP-dependent protein kinase was not involved in the hypoxia-induced increases of the vascular diameter and CBF. In summary, our results suggest that acute hypoxia can induce the opening of Kir channels in coronary artery that has small diameter (<100 mum) by activating the cAMP and PKA signalling pathway, which could contribute to vasodilation and, therefore, increased CBF.en
dc.language.isoenen
dc.publisherSpringer-Verlagen
dc.subjectAcute Diseaseen
dc.subjectAdenine/analogs & derivatives/pharmacologyen
dc.subjectAnimalsen
dc.subjectAnoxia/*physiopathologyen
dc.subjectBlood Pressure/physiologyen
dc.subjectCarbazoles/pharmacologyen
dc.subjectCoronary Circulation/*physiologyen
dc.subjectCyclic AMP-Dependent Protein Kinases/antagonists & inhibitorsen
dc.subjectCyclic GMP/analogs & derivatives/pharmacologyen
dc.subjectCyclic GMP-Dependent Protein Kinases/antagonists & inhibitorsen
dc.subjectEnzyme Inhibitors/pharmacologyen
dc.subjectFemaleen
dc.subjectGlyburide/pharmacologyen
dc.subjectIndoles/pharmacologyen
dc.subjectMaleen
dc.subjectPotassium Channel Blockers/pharmacologyen
dc.subjectPotassium Channels, Inwardly Rectifying/drug effects/*physiologyen
dc.subjectPyrroles/pharmacologyen
dc.subjectRabbitsen
dc.subjectSignal Transduction/physiologyen
dc.subjectVasodilation/*physiologyen
dc.titleAcute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channelsen
dc.typeArticleen
dc.contributor.AlternativeAuthor박원선-
dc.contributor.AlternativeAuthor손연경-
dc.contributor.AlternativeAuthor김나리-
dc.contributor.AlternativeAuthor고재홍-
dc.contributor.AlternativeAuthor강성현-
dc.contributor.AlternativeAuthor엄융의-
dc.contributor.AlternativeAuthor정인덕-
dc.contributor.AlternativeAuthor박영민-
dc.contributor.AlternativeAuthor한진-
dc.identifier.doi10.1007/s00424-007-0269-4-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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