SHERP

Modafinil-induced hippocampal activation in narcolepsy

Cited 0 time in webofscience Cited 11 time in scopus
Authors
Kim, Yu Kyeong; Yoon, In-Young; Shin, Yoon-Kyung; Cho, Sang Soo; Kim, Sang Eun
Issue Date
2007-06-30
Publisher
Elsevier
Citation
Neuroscience Letters 422 (2007) 91-96
Keywords
NarcolepsyModafinilBenzhydryl Compounds/*pharmacology/therapeutic useBrain MappingBrain Stem/drug effects/metabolism/radionuclide imagingCentral Nervous System Stimulants/*pharmacology/therapeutic useEnergy Metabolism/drug effectsFluorodeoxyglucose F18/diagnostic useFunctional Laterality/drug effectsGlucose/metabolismHippocampusHypothalamus/drug effects/metabolism/radionuclide imagingF-18 FDG PETNarcolepsy/*drug therapy/*physiopathology/radionuclide imagingNeural Pathways/drug effects/metabolism/radionuclide imagingPositron-Emission TomographySleepThalamus/drug effects/metabolism/radionuclide imagingTreatment OutcomeWakefulness
Abstract
This study was undertaken to investigate regional metabolic abnormalities and to determine the effects of modafinil in narcoleptics on cerebral glucose metabolism using [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET). Eight narcoleptic patients participated in the study. Two [(18)F] FDG PET scans were obtained before and after 2 weeks of modafinil treatment. To identify the effect of modafinil on regional cerebral abnormalities in narcoleptics, pre- and post-treatment PET scans were compared using paired t-statistics with voxel-wised manner. In narcolepsy patients, significant decreases in cerebral glucose metabolism were observed in the midbrain and upper pons, bilateral hypothalamus, posterior thalamus, hippocampus and right parahippocampus as compared with healthy subjects. After treatment, a significant increase in glucose metabolism in the left hippocampus was found in comparison with pre-treatment scan. This study demonstrated that modafinil activates the hippocampus which receives the afferents from hypothalamus, the center of sleep-wake rhythm.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-4NWNCVD-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fa33829b6e8d371645e272f5f99834c3

http://hdl.handle.net/10371/29352
DOI
https://doi.org/10.1016/j.neulet.2007.04.085
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse