S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
The effects of MK-801 on the phosphorylation of Ser338-c-Raf-MEK-ERK pathway in the rat frontal cortex
- Ahn, Yong Min; Seo, Myoung Suk; Kim, Se Hyun; Kim, Yeni; Juhnn, Yong-Sung; Kim, Yong Sik
- Issue Date
- Cambridge University Press
- Int J Neuropsychopharmacol. 2006 Aug;9(4):451-6. Epub 2005 Aug 4.
- Animals; Dizocilpine Maleate/*pharmacology; Extracellular Signal-Regulated MAP Kinases/metabolism; Frontal Lobe/*drug effects/*enzymology; MAP Kinase Signaling System/*drug effects/physiology; Male; Mitogen-Activated Protein Kinases/*metabolism; Phosphorylation/drug effects; Rats; Rats, Sprague-Dawley
- MK-801 induces psychotomimetic behavioural changes in animals. ERKs play an important role in the pathogenesis of schizophrenia and in the action of antipsychotics and psychotomimetics. We observed phosphorylation of ERK-signalling-pathway-associated molecules in the rat frontal cortex and their association with rat behaviour after MK-801 administration. After injecting 0.25-1 mg/kg MK-801, ERK phosphorylation decreased compared to vehicle treatment, and rats showed increased locomotion. After 2 mg/kg treatment, ERK phosphorylation increased and rat motility started to decrease. After treating with 4-8 mg/kg, ERK phosphorylation once again decreased and rats showed hypomotility and ataxia. ERK phosphorylation levels were maintained from 15 min to 90 min after 1 or 2 mg/kg treatment. Ser338-c-Raf and MEK phosphorylation showed similar dose-dependent and temporal patterns to those of ERK. Taken together, Ser338-c-Raf-MEK-ERK phosphorylation by MK-801 in the rat frontal cortex showed a specific pattern and may be associated with behavioural changes induced by MK-801.
- 1461-1457 (Print)