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The effects of MK-801 on the phosphorylation of Ser338-c-Raf-MEK-ERK pathway in the rat frontal cortex

Cited 15 time in Web of Science Cited 18 time in Scopus
Authors
Ahn, Yong Min; Seo, Myoung Suk; Kim, Se Hyun; Kim, Yeni; Juhnn, Yong-Sung; Kim, Yong Sik
Issue Date
2005-08-05
Publisher
Cambridge University Press
Citation
Int J Neuropsychopharmacol. 2006 Aug;9(4):451-6. Epub 2005 Aug 4.
Keywords
AnimalsDizocilpine Maleate/*pharmacologyExtracellular Signal-Regulated MAP Kinases/metabolismFrontal Lobe/*drug effects/*enzymologyMAP Kinase Signaling System/*drug effects/physiologyMaleMitogen-Activated Protein Kinases/*metabolismPhosphorylation/drug effectsRatsRats, Sprague-Dawley
Abstract
MK-801 induces psychotomimetic behavioural changes in animals. ERKs play an important role in the pathogenesis of schizophrenia and in the action of antipsychotics and psychotomimetics. We observed phosphorylation of ERK-signalling-pathway-associated molecules in the rat frontal cortex and their association with rat behaviour after MK-801 administration. After injecting 0.25-1 mg/kg MK-801, ERK phosphorylation decreased compared to vehicle treatment, and rats showed increased locomotion. After 2 mg/kg treatment, ERK phosphorylation increased and rat motility started to decrease. After treating with 4-8 mg/kg, ERK phosphorylation once again decreased and rats showed hypomotility and ataxia. ERK phosphorylation levels were maintained from 15 min to 90 min after 1 or 2 mg/kg treatment. Ser338-c-Raf and MEK phosphorylation showed similar dose-dependent and temporal patterns to those of ERK. Taken together, Ser338-c-Raf-MEK-ERK phosphorylation by MK-801 in the rat frontal cortex showed a specific pattern and may be associated with behavioural changes induced by MK-801.
ISSN
1461-1457 (Print)
Language
English
URI
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=450209

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16079022

http://hdl.handle.net/10371/29357
DOI
https://doi.org/10.1017/S1461145705005882
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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