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The effects of MK-801 on the phosphorylation of Ser338-c-Raf-MEK-ERK pathway in the rat frontal cortex
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Yong Min | - |
dc.contributor.author | Seo, Myoung Suk | - |
dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Kim, Yeni | - |
dc.contributor.author | Juhnn, Yong-Sung | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.date.accessioned | 2010-01-11T07:07:50Z | - |
dc.date.available | 2010-01-11T07:07:50Z | - |
dc.date.issued | 2005-08-05 | - |
dc.identifier.citation | Int J Neuropsychopharmacol. 2006 Aug;9(4):451-6. Epub 2005 Aug 4. | en |
dc.identifier.issn | 1461-1457 (Print) | - |
dc.identifier.uri | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=450209 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16079022 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29357 | - |
dc.description.abstract | MK-801 induces psychotomimetic behavioural changes in animals. ERKs play an important role in the pathogenesis of schizophrenia and in the action of antipsychotics and psychotomimetics. We observed phosphorylation of ERK-signalling-pathway-associated molecules in the rat frontal cortex and their association with rat behaviour after MK-801 administration. After injecting 0.25-1 mg/kg MK-801, ERK phosphorylation decreased compared to vehicle treatment, and rats showed increased locomotion. After 2 mg/kg treatment, ERK phosphorylation increased and rat motility started to decrease. After treating with 4-8 mg/kg, ERK phosphorylation once again decreased and rats showed hypomotility and ataxia. ERK phosphorylation levels were maintained from 15 min to 90 min after 1 or 2 mg/kg treatment. Ser338-c-Raf and MEK phosphorylation showed similar dose-dependent and temporal patterns to those of ERK. Taken together, Ser338-c-Raf-MEK-ERK phosphorylation by MK-801 in the rat frontal cortex showed a specific pattern and may be associated with behavioural changes induced by MK-801. | en |
dc.language.iso | en | en |
dc.publisher | Cambridge University Press | en |
dc.subject | Animals | en |
dc.subject | Dizocilpine Maleate/*pharmacology | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/metabolism | en |
dc.subject | Frontal Lobe/*drug effects/*enzymology | en |
dc.subject | MAP Kinase Signaling System/*drug effects/physiology | en |
dc.subject | Male | en |
dc.subject | Mitogen-Activated Protein Kinases/*metabolism | en |
dc.subject | Phosphorylation/drug effects | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.title | The effects of MK-801 on the phosphorylation of Ser338-c-Raf-MEK-ERK pathway in the rat frontal cortex | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.contributor.AlternativeAuthor | 서명숙 | - |
dc.contributor.AlternativeAuthor | 김세현 | - |
dc.contributor.AlternativeAuthor | 김예니 | - |
dc.contributor.AlternativeAuthor | 전용성 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.identifier.doi | 10.1017/S1461145705005882 | - |
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