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Increase of interleukin-6 in tracheal aspirate at birth: a predictor of subsequent bronchopulmonary dysplasia in preterm infants

Cited 39 time in Web of Science Cited 46 time in Scopus
Authors
Choi, Chang Won; Kim, Beyong Il; Kim, Han-Suk; Park, June Dong; Choi, Jung-Hwan; Son, Dong Woo
Issue Date
2005-12-24
Publisher
Blackwell Publishing
Citation
Acta Paediatr. 2006 Jan;95(1):38-43.
Keywords
Biological Markers/metabolismBronchopulmonary Dysplasia/*diagnosis/etiology/metabolismChorioamnionitis/metabolismDuctus Arteriosus, Patent/complicationsFemaleHumansInfant, NewbornInfant, Premature/*metabolismInterleukin-6/*metabolismIntubation, IntratrachealLogistic ModelsPneumonia/complications/metabolismPredictive Value of TestsPregnancyProspective StudiesRisk FactorsTrachea/*metabolism
Abstract
AIM: We tested whether interleukin-6 (IL-6) in tracheal aspirate (TA) at birth, as a marker of fetal pulmonary inflammation, can be a predictor of bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: A total of 75 preterm (< or = 32 wk) infants who were intubated in the delivery room were prospectively enrolled. Multivariate logistic regression analysis was done to determine whether IL-6 in TA at birth is an independent risk factor for BPD, and a receiver-operating characteristic curve was constructed to determine the accuracy of IL-6 in TA for predicting the risk of BPD. RESULTS: IL-6 in TA at birth was an independent risk factor for BPD. Fetal pulmonary inflammation defined as IL-6 in TA at birth > or = 316 pg/ml together with patent ductus arteriosus (PDA) additively predicted the risk of BPD. The sensitivity, specificity, and positive and negative predictive values of fetal pulmonary inflammation for the identification of BPD were 73%, 71%, 58% and 83%, respectively. CONCLUSION: IL-6 in TA at birth can be used as a predictor of BPD in combination with the presence of PDA.
ISSN
0803-5253 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16373294

http://hdl.handle.net/10371/29371
DOI
https://doi.org/10.1080/08035250500404085
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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