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Increase of interleukin-6 in tracheal aspirate at birth: a predictor of subsequent bronchopulmonary dysplasia in preterm infants

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dc.contributor.authorChoi, Chang Won-
dc.contributor.authorKim, Beyong Il-
dc.contributor.authorKim, Han-Suk-
dc.contributor.authorPark, June Dong-
dc.contributor.authorChoi, Jung-Hwan-
dc.contributor.authorSon, Dong Woo-
dc.date.accessioned2010-01-11T07:14:27Z-
dc.date.available2010-01-11T07:14:27Z-
dc.date.issued2005-12-24-
dc.identifier.citationActa Paediatr. 2006 Jan;95(1):38-43.en
dc.identifier.issn0803-5253 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16373294-
dc.identifier.urihttps://hdl.handle.net/10371/29371-
dc.description.abstractAIM: We tested whether interleukin-6 (IL-6) in tracheal aspirate (TA) at birth, as a marker of fetal pulmonary inflammation, can be a predictor of bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: A total of 75 preterm (< or = 32 wk) infants who were intubated in the delivery room were prospectively enrolled. Multivariate logistic regression analysis was done to determine whether IL-6 in TA at birth is an independent risk factor for BPD, and a receiver-operating characteristic curve was constructed to determine the accuracy of IL-6 in TA for predicting the risk of BPD. RESULTS: IL-6 in TA at birth was an independent risk factor for BPD. Fetal pulmonary inflammation defined as IL-6 in TA at birth > or = 316 pg/ml together with patent ductus arteriosus (PDA) additively predicted the risk of BPD. The sensitivity, specificity, and positive and negative predictive values of fetal pulmonary inflammation for the identification of BPD were 73%, 71%, 58% and 83%, respectively. CONCLUSION: IL-6 in TA at birth can be used as a predictor of BPD in combination with the presence of PDA.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectBiological Markers/metabolismen
dc.subjectBronchopulmonary Dysplasia/*diagnosis/etiology/metabolismen
dc.subjectChorioamnionitis/metabolismen
dc.subjectDuctus Arteriosus, Patent/complicationsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subjectInfant, Premature/*metabolismen
dc.subjectInterleukin-6/*metabolismen
dc.subjectIntubation, Intratrachealen
dc.subjectLogistic Modelsen
dc.subjectPneumonia/complications/metabolismen
dc.subjectPredictive Value of Testsen
dc.subjectPregnancyen
dc.subjectProspective Studiesen
dc.subjectRisk Factorsen
dc.subjectTrachea/*metabolismen
dc.titleIncrease of interleukin-6 in tracheal aspirate at birth: a predictor of subsequent bronchopulmonary dysplasia in preterm infantsen
dc.typeArticleen
dc.contributor.AlternativeAuthor최창원-
dc.contributor.AlternativeAuthor김병일-
dc.contributor.AlternativeAuthor김한석-
dc.contributor.AlternativeAuthor박준동-
dc.contributor.AlternativeAuthor최정환-
dc.contributor.AlternativeAuthor손동우-
dc.identifier.doi10.1080/08035250500404085-
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