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Human metapneumovirus infection in hospitalized children with acute respiratory disease in Korea

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Authors
Chung, Ju Young; Han, Tae Hee; Kim, Byung Eui; Kim, Chang Keun; Kim, Sang Woo; Hwang, Eung-Soo
Issue Date
2006-10-18
Publisher
Korean Academy of Medical Science
Citation
J Korean Med Sci. 2006 Oct;21(5):838-42.
Keywords
Acute DiseaseChildChild, PreschoolFemaleHospitalizationHumansInfantMaleMetapneumovirus/classification/*isolation & purificationParamyxoviridae Infections/*epidemiologyPhylogenyRespiratory Tract Infections/*etiologyReverse Transcriptase Polymerase Chain Reaction
Abstract
Human metapneumovirus (hMPV) is a recently isolated virus, mostly associated with acute lower respiratory infection in children, of which symptoms are similar to those of respiratory syncytial virus (RSV) infection. The aim of our study was to determine the frequency of hMPV in hospitalized children with acute respiratory tract disease in Korea. Nasal aspirates from hospitalized children with respiratory infections under 15 yr old between December 2003 and February 2005 were included in the study. Each sample was analyzed for RSV, adenovirus, influenza virus A and B, and parainfluenza virus by indirect fluorescent assay (IFA). F-gene sequences were used for PCR for the detection and sequencing of hMPV. In total 381 samples, negative samples in which any viral pathogen could not be identified by IFA were 231 cases. hMPV was detected using reverse transcriptase-PCR (RT-PCR) in 28 of 231 (12.1%) children who were not infected with another respiratory viruses. The hMPV-infected children were diagnosed as having pneumonia, bronchiolitis, bronchial asthma exacerbation, croup, and upper respiratory tract infection. Most of the RT-PCR positive samples for hMPV were collected in winter season. These results suggest that hMPV may be a responsible pathogen causing acute respiratory tract infection in Korean children.
ISSN
1011-8934 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17043416

http://hdl.handle.net/10371/29372
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College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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