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Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Koh, Sang Hyeok | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Jeong, Gajin | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.date.accessioned | 2010-01-11T07:36:10Z | - |
dc.date.available | 2010-01-11T07:36:10Z | - |
dc.date.issued | 2007-10-24 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2007 Dec 14;364(2):388-94. Epub 2007 Oct 15. | en |
dc.identifier.issn | 1090-2104 (Electronic) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4PX127K-9&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=21b0704be66470e71da7f0936b25e444 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17950696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29397 | - |
dc.description.abstract | Hypoxia is known to regulate the expression of genes involved in the migration of various cell types. Although many studies have shown that hypoxia increases cell migration, it still remains unclear whether hypoxia could modulate the stromal cell derived factor-1 (SDF-1)-dependent migration of leukemic cell. Herein, we demonstrated that the SDF-1-dependent migration of HL-60, was reduced under hypoxia with no comparable decrease of CXC-type chemokine receptor CXCR4, a cognate receptor for SDF-1. Furthermore, we showed that migration toward SDF-1 was reduced by inactivation of either serine/threonine kinase Akt or extracellular signal regulated kinase Erk, which was confirmed by selective pathway inhibitor LY294002 and PD98059. In our results, phosphorylation of Erk was increased under hypoxia, but phosphorylation of Akt was attenuated on the contrary. These results led us to conclusion that hypoxia could inhibit the SDF-1-dependent migration of HL-60 via blocking of Akt activation. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Cell Hypoxia | en |
dc.subject | Chemokine CXCL12/*metabolism | en |
dc.subject | Chemotaxis | en |
dc.subject | Chromones/pharmacology | en |
dc.subject | Enzyme Inhibitors/pharmacology | en |
dc.subject | Flavonoids/pharmacology | en |
dc.subject | HL-60 Cells | en |
dc.subject | Humans | en |
dc.subject | Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis | en |
dc.subject | Morpholines/pharmacology | en |
dc.subject | Phosphorylation | en |
dc.subject | Proto-Oncogene Proteins c-akt/antagonists & inhibitors/*metabolism | en |
dc.subject | Receptors, CXCR4/biosynthesis | en |
dc.title | Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 서영진 | - |
dc.contributor.AlternativeAuthor | 고상혁 | - |
dc.contributor.AlternativeAuthor | 강형진 | - |
dc.contributor.AlternativeAuthor | 신희영 | - |
dc.contributor.AlternativeAuthor | 정가진 | - |
dc.contributor.AlternativeAuthor | 안효섭 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.10.023 | - |
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