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A phase II trial of S-1 and cisplatin in patients with metastatic or relapsed biliary tract cancer

Cited 28 time in Web of Science Cited 31 time in Scopus
Authors
Kim, Y. J.; Im, Seock-Ah; Kim, H. G.; Oh, S. Y.; Lee, K. W.; Choi, I. S.; Oh, Do-Youn; Lee, S. H.; Kim, JeeHyun; Kim, Dong-Wan; Kim, Tae-You; Kim, S. W.; Heo, Dae Seog; Yoon, Y. B.; Bang, Yung-Jue
Issue Date
2008-01
Publisher
Oxford University Press
Citation
Annals of Oncology, Vol.19 No.1, pp.99-103
Keywords
biliary tract cancercisplatinS-1
Abstract
Background: Optimal chemotherapy for advanced biliary tract cancer (BTC) is yet to be defined. We carried out this study to evaluate the efficacy and toxicity of combination chemotherapy with S-1 and cisplatin in metastatic or relapsed BTC. Patients and methods: Patients with pathologically proven BTC were eligible. The chemotherapy regimen consisted of S-1 (40 mg/m(2) p.o. b.i.d. from D1-14) and cisplatin (60 mg/m(2) on D1), repeated every 3 weeks. Results: Fifty-one BTC patients (metastatic: relapsed = 37:14, Gall-bladder: intrahepatic bile ducts: extrahepatic bile ducts = 16:25:10) were enrolled from January 2005 to December 2006. Median age was 57 years (range, 31-71) and most patients had a good performance status. The overall response rate was 30% [95% confidence interval (Cl), 17.3-42.7] and complete response was observed in two patients (4%), partial response in 13 (26%), stable disease in 21 (42%), and progressive disease in 9 (18%). With a median follow-up of 12.4 months, the median time to progression was 4.8 months (95% Cl, 3.3-6.3) and median overall survival was 8.7 months (95% Cl, 6.0-11.4). Major toxic effects were grade 3/4 neutropenia (8.9% of all cycles) and febrile neutropenia was observed in six cycles (2.7% of all cycles). Conclusion: Combination chemotherapy with S-1 and cisplatin was a moderately effective outpatient-based regimen in BTC patients. Toxic effects were moderate but manageable.
ISSN
0923-7534
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17846018

http://hdl.handle.net/10371/29525
DOI
https://doi.org/10.1093/annonc/mdm439
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
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