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Fractal dimension in human cortical surface: multiple regression analysis with cortical thickness, sulcal depth, and folding area

Cited 93 time in Web of Science Cited 97 time in Scopus
Authors
Im, Kiho; Lee, Jong-Min; Yoon, Uicheul; Shin, Yong-Wook; Hong, Soon Beom; Kim, In Young; Kwon, Jun Soo; Kim, Sun I
Issue Date
2006-05-04
Publisher
Wiley-Blackwell
Citation
Hum Brain Mapp. 2006 Dec;27(12):994-1003.
Keywords
Adult*Brain MappingCerebral Cortex/*anatomy & histology/physiologyEducational StatusFemale*FractalsFunctional Laterality/physiologyHumansImaging, Three-Dimensional/methodsIntelligenceMagnetic Resonance Imaging/methodsMale*Regression Analysis
Abstract
Fractal dimension (FD) has been widely used to provide a quantitative description of structural complexity in the cerebral cortex. FD is an extremely compact measure of shape complexity, condensing all details into a single numeric value. We interpreted the variation of the FD in the cortical surface of normal controls through multiple regression analysis with cortical thickness, sulcal depth, and folding area related to cortical complexity. We used a cortical surface showing a reliable representation of folded gyri and manually parcellated it into frontal, parietal, temporal, and occipital regions for regional analysis. In both hemispheres the mean cortical thickness and folding area showed significant combination effects on cortical complexity and accounted for about 50% of its variance. The folding area was significant in accounting for the FD of the cortical surface, with positive coefficients in both hemispheres and several lobe regions, while sulcal depth was significant only in the left temporal region. The results may suggest that human cortex develops a complex structure through the thinning of cortical thickness and by increasing the frequency of folds and the convolution of gyral shape rather than by deepening sulcal regions. Through correlation analysis of FD with IQ and the number of years of education, the results showed that a complex shape of the cortical surface has a significant relationship with intelligence and education. Our findings may indicate the structural characteristics that are revealed in the cerebral cortex when the FD in human brain is increased, and provide important information about brain development.
ISSN
1065-9471 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16671080

http://hdl.handle.net/10371/29529
DOI
https://doi.org/10.1002/hbm.20238
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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