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A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
Cited 73 time in
Web of Science
Cited 80 time in Scopus
- Authors
- Issue Date
- 2006-07-04
- Publisher
- American Psychiatric Publishing
- Citation
- Am J Psychiatry. 2006 Jul;163(7):1202-7.
- Keywords
- Adult ; Aspartic Acid/*analogs & derivatives/metabolism ; Brain/drug effects/*metabolism ; Brain Chemistry/drug effects ; Choline/metabolism ; Citalopram/*pharmacokinetics/*therapeutic use ; Creatine/metabolism ; Female ; Frontal Lobe/drug effects/metabolism ; Gyrus Cinguli/drug effects/metabolism ; Humans ; Longitudinal Studies ; Male ; Obsessive-Compulsive Disorder/diagnosis/*drug therapy/metabolism ; Personality Inventory ; Prefrontal Cortex/drug effects/metabolism ; Protons ; Psychiatric Status Rating Scales ; Serotonin Uptake Inhibitors/*pharmacokinetics/*therapeutic use ; Magnetic Resonance Spectroscopy
- Abstract
- OBJECTIVE: Reductions in the level of N-acetylaspartate within subcortical structures of patients with obsessive-compulsive disorder (OCD) have been reported in several studies. However, there have been, as yet, no reports regarding N-acetylaspartate levels in the prefrontal cortex of adult drug-naive OCD patients. The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were included in this study. N-acetylaspartate levels (obtained from ratios of N-acetylaspartate with creatine, choline, and creatine plus choline) in the prefrontal cortex, parietal cortex, anterior cingulate, posterior cingulate, frontal white matter, and parietal white matter were measured by (1)H-MRSI. In OCD patients, measurements were taken before and after 12 weeks of citalopram treatment. Correlations between N-acetylaspartate concentrations in regions of interest and clinical measures were also assessed. RESULTS: Drug-naive OCD patients exhibited significantly lower N-acetylaspartate levels in the prefrontal cortex, frontal white matter, and anterior cingulate at baseline than did comparison subjects. Significant increases in N-acetylaspartate level were detected in the prefrontal cortex and frontal white matter in OCD patients after 12 weeks of citalopram treatment. CONCLUSIONS: These data suggest that reductions in neuronal viability occur in the frontal region of OCD patients and that these reductions may be partly reversible.
- ISSN
- 0002-953X (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16816225
https://hdl.handle.net/10371/29582
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