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Preliminary results of pre-radiation neck dissection in head and neck cancer patients undergoing organ preservation treatment
Cited 1 time in
Web of Science
Cited 1 time in Scopus
- Authors
- Issue Date
- 2007-11-21
- Publisher
- Scandinavian University Press
- Citation
- Acta Otolaryngol Suppl. 2007 Oct;(558):121-7.
- Keywords
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bridged Compounds/administration & dosage ; Carcinoma, Squamous Cell/*mortality/pathology/*therapy ; Chemotherapy, Adjuvant ; Cisplatin/administration & dosage ; Disease-Free Survival ; Female ; Fluorouracil/administration & dosage ; Head and Neck Neoplasms/*mortality/pathology/*therapy ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/epidemiology ; Radiotherapy Dosage ; Taxoids/administration & dosage ; Neck Dissection ; Radiotherapy, Adjuvant
- Abstract
- CONCLUSION: Pre-RT ND in patients with HNSCC undergoing organ preservation treatment is safe, advantageous, poses no additional morbidity owing to the elective neck dissection, and may possibly improve survival outcomes. OBJECTIVE: Establish the role of pre-radiation neck dissection (pre-RT ND) in patients with head & neck squamous cell carcinoma (HNSCC) undergoing organ preservation treatment. MATERIALS AND METHODS: Fourteen patients with histologically confirmed HNSCC in stages III approximately IV with proven regional metastasis were enrolled in the organ preservation approach incorporating pre-RT ND at a tertiary referral center between May 1998 and August 2004. Site matched patients treated with organ preservation intent in the conventional fashion were used as controls. Data were collected for their diagnosis, management, treatment outcome, and follow up. RESULTS: Disease free survival was significantly better for the pre-RT ND group. There was no significant difference in overall survival, pattern of recurrence, and primary organ preservation rate between the two groups. No significant morbidity owing to neck dissection was noted in patients who underwent neck dissection. Although the delivery of radiation to the primary site was delayed for patients in the pre-RT ND group, it did not influence the major outcomes.
- ISSN
- 0365-5237 (Print)
- Language
- English
- URI
- http://www.informaworld.com/smpp/content~db=all?content=10.1080/03655230701625001
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17882582
https://hdl.handle.net/10371/29720
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