Preliminary results of pre-radiation neck dissection in head and neck cancer patients undergoing organ preservation treatment

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Jeong, Woo-Jin; Jung, Eun-Jung; Hah, J Hun; Kwon, Tack-Kyun; Wu, Hong-Gyun; Heo, Dae Seog; Sung, Myung-Whun; Kim, Kwang Hyun
Issue Date
Scandinavian University Press
Acta Otolaryngol Suppl. 2007 Oct;(558):121-7.
Antineoplastic Combined Chemotherapy Protocols/therapeutic useBridged Compounds/administration & dosageCarcinoma, Squamous Cell/*mortality/pathology/*therapyChemotherapy, AdjuvantCisplatin/administration & dosageDisease-Free SurvivalFemaleFluorouracil/administration & dosageHead and Neck Neoplasms/*mortality/pathology/*therapyHumansMaleMiddle Aged*Neck DissectionNeoplasm MetastasisNeoplasm Recurrence, Local/epidemiologyRadiotherapy Dosage*Radiotherapy, AdjuvantTaxoids/administration & dosage
CONCLUSION: Pre-RT ND in patients with HNSCC undergoing organ preservation treatment is safe, advantageous, poses no additional morbidity owing to the elective neck dissection, and may possibly improve survival outcomes. OBJECTIVE: Establish the role of pre-radiation neck dissection (pre-RT ND) in patients with head & neck squamous cell carcinoma (HNSCC) undergoing organ preservation treatment. MATERIALS AND METHODS: Fourteen patients with histologically confirmed HNSCC in stages III approximately IV with proven regional metastasis were enrolled in the organ preservation approach incorporating pre-RT ND at a tertiary referral center between May 1998 and August 2004. Site matched patients treated with organ preservation intent in the conventional fashion were used as controls. Data were collected for their diagnosis, management, treatment outcome, and follow up. RESULTS: Disease free survival was significantly better for the pre-RT ND group. There was no significant difference in overall survival, pattern of recurrence, and primary organ preservation rate between the two groups. No significant morbidity owing to neck dissection was noted in patients who underwent neck dissection. Although the delivery of radiation to the primary site was delayed for patients in the pre-RT ND group, it did not influence the major outcomes.
0365-5237 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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