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Long-term depression of mGluR1 signaling

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Authors
Kim, Sang Jeong; Jin, Yunju; Kim, Jun; Worley, Paul F.; Linden, David J.
Issue Date
2007-07-21
Publisher
Cell Press
Citation
Neuron. 2007 Jul 19;55(2):277-87.
Keywords
AnimalsCalcium Signaling/physiologyExcitatory Postsynaptic Potentials/*physiologyLong-Term Synaptic Depression/*physiologyNerve Fibers/metabolismPatch-Clamp TechniquesPurkinje Cells/*metabolismRatsRats, Sprague-DawleyReceptors, Metabotropic Glutamate/*metabolismSynaptic Transmission/*physiology
Abstract
Glutamate produces both fast excitation through activation of ionotropic receptors and slower actions through metabotropic receptors (mGluRs). To date, ionotropic but not metabotropic neurotransmission has been shown to undergo long-term synaptic potentiation and depression. Burst stimulation of parallel fibers releases glutamate, which activates perisynaptic mGluR1 in the dendritic spines of cerebellar Purkinje cells. Here, we show that the mGluR1-dependent slow EPSC and its coincident Ca transient were selectively and persistently depressed by repeated climbing fiber-evoked depolarization of Purkinje cells in brain slices. LTD(mGluR1) was also observed when slow synaptic current was evoked by exogenous application of a group I mGluR agonist, implying a postsynaptic expression mechanism. Ca imaging further revealed that LTD(mGluR1) was expressed as coincident attenuation of both limbs of mGluR1 signaling: the slow EPSC and PLC/IP3-mediated dendritic Ca mobilization. Thus, different patterns of neural activity can evoke LTD of either fast ionotropic or slow mGluR1-mediated synaptic signaling.
ISSN
0896-6273 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17640528

http://hdl.handle.net/10371/29742
DOI
https://doi.org/10.1016/j.neuron.2007.06.035
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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