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Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice

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Authors
Im, Heh-In; Joo, Wan Seok; Nam, Eunjoo; Lee, Eun-sun; Hwang, Yu-jin; Kim, Yong Sik
Issue Date
2005-06-09
Publisher
Japanese Pharmacological Society
Citation
J Pharmacol Sci. 2005 Jun;98(2):185-9. Epub 2005 Jun 8.
Keywords
AnimalsDopamine/*physiologyFlavanones/*pharmacologyInjections, IntraventricularLipid Peroxidation/*drug effectsMiceNeuroprotective Agents/*pharmacologyOxidopamine/administration & dosage/*pharmacologyPsychomotor Performance/drug effects
Abstract
The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalein daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action.
ISSN
1347-8613 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15942123

http://hdl.handle.net/10371/29744
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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