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Basal ganglia shape alterations in bipolar disorder

Cited 72 time in Web of Science Cited 77 time in Scopus
Authors
Hwang, Jaeuk; Lyoo, In Kyoon; Dager, Stephen R; Friedman, Seth D; Oh, Jung Su; Lee, Jun Young; Kim, Seog Ju; Dunner, David L; Renshaw, Perry F
Issue Date
2006-02-02
Publisher
American Psychiatric Publishing
Citation
Am J Psychiatry. 2006 Feb;163(2):276-85.
Keywords
AdultAntipsychotic Agents/pharmacology/therapeutic useBasal Ganglia/*anatomy & histology/drug effectsBipolar Disorder/*diagnosis/drug therapyBrain Mapping/methodsCaudate Nucleus/anatomy & histology/drug effectsCorpus Striatum/anatomy & histology/drug effectsFemaleHumansImaging, Three-Dimensional/methodsLithium/pharmacology/therapeutic useMagnetic Resonance Imaging/methods/statistics & numerical dataMalePutamen/anatomy & histology/drug effects
Abstract
OBJECTIVE: Shape differences in the caudate heads and putamen were compared between drug-naive and drug-treated patients with bipolar disorder and healthy comparison subjects by using spherical harmonic (SPHARM) techniques. On the basis of previous studies, the authors hypothesized that the drug-naive patients would exhibit shape differences of the caudate heads and putamen, especially on the right side, relative to the healthy comparison subjects, and that shape differences, relative to healthy comparison subjects, would differ between drug-naive and drug-treated patients. METHOD: Brain magnetic resonance images were acquired from 49 bipolar disorder patients (21 drug-naive and 28 drug-treated patients) and 37 healthy comparison subjects. Volumetric measurements were obtained, and SPHARM descriptions were used to measure between-group radius differences in the surfaces of the caudate heads and putamen. RESULTS: Although no significant between-group volume differences were found in the striatal structures, significant shape differences in the anterior and ventral surfaces of the striatum were observed. Specifically, shape differences, more prominent for the right side, were found for drug-naive bipolar disorder patients, relative to the healthy comparison subjects, but not for drug-treated bipolar disorder subjects. CONCLUSIONS: The findings suggest that drug-naive bipolar disorder patients have shape differences of the striatum, relative to healthy comparison subjects, and that these differences may be modulated by treatment. The findings more generally demonstrate the sensitivity of the SPHARM analytic technique for detecting subtle anatomical shape differences in small brain regions in the absence of volume differences.
ISSN
0002-953X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16449482

http://hdl.handle.net/10371/29790
DOI
https://doi.org/10.1176/appi.ajp.163.2.276
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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