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Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Ji-Hyun | - |
dc.contributor.author | Koh, Young-Sang | - |
dc.contributor.author | Lee, Keun-Hwa | - |
dc.contributor.author | Hyun, Jin-Won | - |
dc.contributor.author | Choi, Yeon-Joo | - |
dc.contributor.author | Jang, Won-Jong | - |
dc.contributor.author | Park, Kyung-Hee | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.contributor.author | Seong, Seung-Yong | - |
dc.contributor.author | Choi, Myung-Sik | - |
dc.contributor.author | Kim, Ik-Sang | - |
dc.date.accessioned | 2010-01-13T02:24:38Z | - |
dc.date.available | 2010-01-13T02:24:38Z | - |
dc.date.issued | 2005-06-21 | - |
dc.identifier.citation | Microbiol Immunol. 2005;49(6):551-7. | en |
dc.identifier.issn | 0385-5600 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15965303 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29821 | - |
dc.description.abstract | To understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production in susceptible (C3H/HeN) and resistant (BALB/c) mice after infection with O. tsutsugamushi Gilliam. C3H/HeN mice produced high levels of chemokines macrophage inflammatory proteins 1 alpha (MIP-1 alpha ), MIP-2, monocyte chemoattractant protein 1 (MCP-1), and cytokines gamma-interferon (IFN-gamma ), interleukin-12 (IL-12), IL-10, and tumor necrosis factor alpha (TNF-alpha ) in response to O. tsutsugamushi infection, compared to BALB/c mice. Chemokine profiles in infected mice correlated well with the kinetics of inflammatory cell infiltration. Hyperproduction of chemokines and cytokines was observed in another susceptible-infection model (BALB/c-Karp). These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Animals | en |
dc.subject | Chemokines/*biosynthesis/genetics/metabolism | en |
dc.subject | Cytokines/*biosynthesis/genetics | en |
dc.subject | Interleukin-10/biosynthesis | en |
dc.subject | Interleukin-12/biosynthesis | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred BALB C | en |
dc.subject | Mice, Inbred C3H | en |
dc.subject | Scrub Typhus/etiology/genetics/*immunology | en |
dc.subject | Tumor Necrosis Factor-alpha/biosynthesis/genetics | en |
dc.subject | Orientia tsutsugamushi | - |
dc.title | Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 윤지현 | - |
dc.contributor.AlternativeAuthor | 고영상 | - |
dc.contributor.AlternativeAuthor | 이근화 | - |
dc.contributor.AlternativeAuthor | 현진원 | - |
dc.contributor.AlternativeAuthor | 최연주 | - |
dc.contributor.AlternativeAuthor | 장원종 | - |
dc.contributor.AlternativeAuthor | 박경희 | - |
dc.contributor.AlternativeAuthor | 조남혁 | - |
dc.contributor.AlternativeAuthor | 성승용 | - |
dc.contributor.AlternativeAuthor | 최명식 | - |
dc.contributor.AlternativeAuthor | 김익상 | - |
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