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Brain white-matter hyperintensities and treatment outcome in major depressive disorder
Cited 47 time in
Web of Science
Cited 60 time in Scopus
- Authors
- Issue Date
- 2006
- Publisher
- Royal College of Psychiatrists
- Citation
- British Journal of Psychiatry,188:180-185
- Keywords
- Age Factors ; Antidepressive Agents/therapeutic use ; Brain/*pathology ; Cardiovascular Diseases/etiology/pathology ; Depressive Disorder, Major/complications/drug therapy/*pathology ; Humans ; Hypertension/etiology/pathology ; Magnetic Resonance Imaging/methods ; Risk Factors ; Severity of Illness Index ; Treatment Outcome
- Abstract
- BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression.
- ISSN
- 0007-1250 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16449707
https://hdl.handle.net/10371/29859
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