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Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Jae-Sung | - |
dc.contributor.author | Yang, Hye-Ran | - |
dc.contributor.author | Chang, Ju-Young | - |
dc.contributor.author | Seo, Jeong-Kee | - |
dc.date.accessioned | 2010-01-14T18:20:20Z | - |
dc.date.available | 2010-01-14T18:20:20Z | - |
dc.date.issued | 2007-04-28 | - |
dc.identifier.citation | World J Gastroenterol. 2007 Apr 7;13(13):1962-5. | en |
dc.identifier.issn | 1007-9327 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17461497 | - |
dc.identifier.uri | https://hdl.handle.net/10371/30201 | - |
dc.description.abstract | AIM: To determine whether Lactobacillus plantarum can modify the deleterious effects of tumor necrosis factor-alpha (TNF-alpha) on intestinal epithelial cells. METHODS: Caco-2 cells were incubated with TNF-alpha alone or in the presence of L. plantarum. Transepithelial electrical resistance was used to measure epithelial barrier function. Interleukin 8 (IL-8) secretion by intestinal epithelial cells was measured using an ELISA. Cellular lysate proteins were immunoblotted using the anti-extracellular regulated kinase (ERK), anti-phospho-ERK and anti-IkappaB-alpha. RESULTS: A TNF-alpha-induced decrease in transepithelial electrical resistance was inhibited by L. plantarum. TNF-alpha-induced IL-8 secretion was reduced by L. plantarum. L. plantarum inhibited the activation of ERK and the degradation of IkappaB-alpha in TNF-alpha-treated Caco-2 cells. CONCLUSION: Induction of epithelial barrier dysfunction and IL-8 secretion by TNF-alpha is inhibited by L. plantarum. Probiotics may preserve epithelial barrier function and inhibit the inflammatory response by altering the signal transduction pathway. | en |
dc.language.iso | en | en |
dc.subject | Adenocarcinoma/metabolism/pathology/physiopathology | en |
dc.subject | Caco-2 Cells | en |
dc.subject | Colonic Neoplasms/metabolism/pathology/physiopathology | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/metabolism | en |
dc.subject | Humans | en |
dc.subject | I-kappa B Proteins/metabolism | en |
dc.subject | Interleukin-8/*metabolism | en |
dc.subject | Intestinal Absorption/drug effects/*physiology | en |
dc.subject | Intestinal Mucosa/drug effects/*physiology | en |
dc.subject | Membrane Potentials/drug effects/physiology | en |
dc.subject | Probiotics/*pharmacology | en |
dc.subject | Tumor Necrosis Factor-alpha/*pharmacology | en |
dc.subject | Lactobacillus plantarum | - |
dc.title | Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 고재성 | - |
dc.contributor.AlternativeAuthor | 양혜란 | - |
dc.contributor.AlternativeAuthor | 장주영 | - |
dc.contributor.AlternativeAuthor | 서정기 | - |
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