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Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha

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dc.contributor.authorKo, Jae-Sung-
dc.contributor.authorYang, Hye-Ran-
dc.contributor.authorChang, Ju-Young-
dc.contributor.authorSeo, Jeong-Kee-
dc.date.accessioned2010-01-14T18:20:20Z-
dc.date.available2010-01-14T18:20:20Z-
dc.date.issued2007-04-28-
dc.identifier.citationWorld J Gastroenterol. 2007 Apr 7;13(13):1962-5.en
dc.identifier.issn1007-9327 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17461497-
dc.identifier.urihttps://hdl.handle.net/10371/30201-
dc.description.abstractAIM: To determine whether Lactobacillus plantarum can modify the deleterious effects of tumor necrosis factor-alpha (TNF-alpha) on intestinal epithelial cells. METHODS: Caco-2 cells were incubated with TNF-alpha alone or in the presence of L. plantarum. Transepithelial electrical resistance was used to measure epithelial barrier function. Interleukin 8 (IL-8) secretion by intestinal epithelial cells was measured using an ELISA. Cellular lysate proteins were immunoblotted using the anti-extracellular regulated kinase (ERK), anti-phospho-ERK and anti-IkappaB-alpha. RESULTS: A TNF-alpha-induced decrease in transepithelial electrical resistance was inhibited by L. plantarum. TNF-alpha-induced IL-8 secretion was reduced by L. plantarum. L. plantarum inhibited the activation of ERK and the degradation of IkappaB-alpha in TNF-alpha-treated Caco-2 cells. CONCLUSION: Induction of epithelial barrier dysfunction and IL-8 secretion by TNF-alpha is inhibited by L. plantarum. Probiotics may preserve epithelial barrier function and inhibit the inflammatory response by altering the signal transduction pathway.en
dc.language.isoenen
dc.subjectAdenocarcinoma/metabolism/pathology/physiopathologyen
dc.subjectCaco-2 Cellsen
dc.subjectColonic Neoplasms/metabolism/pathology/physiopathologyen
dc.subjectExtracellular Signal-Regulated MAP Kinases/metabolismen
dc.subjectHumansen
dc.subjectI-kappa B Proteins/metabolismen
dc.subjectInterleukin-8/*metabolismen
dc.subjectIntestinal Absorption/drug effects/*physiologyen
dc.subjectIntestinal Mucosa/drug effects/*physiologyen
dc.subjectMembrane Potentials/drug effects/physiologyen
dc.subjectProbiotics/*pharmacologyen
dc.subjectTumor Necrosis Factor-alpha/*pharmacologyen
dc.subjectLactobacillus plantarum-
dc.titleLactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alphaen
dc.typeArticleen
dc.contributor.AlternativeAuthor고재성-
dc.contributor.AlternativeAuthor양혜란-
dc.contributor.AlternativeAuthor장주영-
dc.contributor.AlternativeAuthor서정기-
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