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TGF-h1-mediated activations of c-Src and Rac1 modulate levels of cyclins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Kim, Hwang-Phill | - |
dc.contributor.author | Kim, Tai-Young | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Jong, Hyun-Soon | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2009-05-15T04:26:10Z | - |
dc.date.available | 2009-05-15T04:26:10Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Biochim. Biophys. Acta 1743 (2005) 151– 161 | en |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.uri | http://www.elsevier.com/locate/bba | - |
dc.identifier.uri | https://hdl.handle.net/10371/3240 | - |
dc.description.abstract | Integrin-mediated cell adhesion transduces signals to regulate actin cytoskeleton and cell proliferation. While understanding how integrin
signals cross-talk with the TGF-h1 pathways, we observed lamellipodia formation and cyclin regulation in Hep3B cells, following TGF-h1 treatment. To answer if integrin signaling via actin organization might regulate cell cycle progression after TGF-h1 treatment, we analyzed cross-talk between the two receptor-mediated pathways in hepatoma cells on specific ECMs. We found that basal and TGF-h1-mediated activation of c-Src and Rac1, expression of cyclins E and A, and suppression of p27Kip1 were significant in cells replated on fibronectin, but not in cells on collagen I, indicating a different integrin-mediated cellular response to TGF-h1 treatment. Levels of tyrosine phosphorylation and actin-enriched lamellipodia on fibronectin were also more prominent than in cells on collagen I. Studies using pharmacological inhibitors or transient transfections revealed that the preferential TGF-h1 effects in cells on fibronectin required c-Src family kinase activity. These observations suggest that a specific cross-talk between TGF-h1 and fibronectin-binding integrin signal pathways leads to the activation of c- Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells. Therefore, this study represents another mechanism to regulate cell cycle regulators when integrin signaling is collaborative with TGF-h1 pathways. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Integrin | en |
dc.subject | TGF-h1 | en |
dc.subject | Cyclin | en |
dc.subject | Signal cross-talk | en |
dc.subject | c-Src | en |
dc.subject | Rac1 | en |
dc.title | TGF-h1-mediated activations of c-Src and Rac1 modulate levels of cyclins | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.contributor.AlternativeAuthor | 김황필 | - |
dc.contributor.AlternativeAuthor | 김태영 | - |
dc.contributor.AlternativeAuthor | 이미숙 | - |
dc.contributor.AlternativeAuthor | 종현순 | - |
dc.contributor.AlternativeAuthor | 김태유 | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/j.bbamcr.2004.09.014 | - |
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