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Mucoepidermoid carcinoma of lung: Potential target of EGFR-directed treatment

Cited 56 time in Web of Science Cited 65 time in Scopus
Authors
Han, Sae-Won; Kim, Hwang-Phill; Jeon, Yoon Kyung; Oh, Do-Youn; Lee, Se-Hoon; Kim, Dong-Wan; Im, Seock-Ah; Chung, Doo Hyun; Heo, Dae Seog; Bang, Yung-Jue; Kim, Tae-You
Issue Date
2008-07
Publisher
Elsevier
Citation
Lung Cancer, Vol.61 No.1, pp.30-34
Keywords
mucoepidermoid carcinomaEGFRmutationgefitiniblung cancerL858R
Abstract
Mucoepidermoid carcinoma (MEC) of lung is a rare malignancy of lung which originates from minor salivary glands of tracheobronchial tree. EGFR targeted therapy by inhibition of EGFR activation with the specific tyrosine kinase inhibitors (TKIs) has shown meaningful antitumor activity in patients with EGFR TK mutation and/or amplification, or in patients with adenocarcinoma. In the present study, we find that MEC has EGFR mutation in 40% (2 out of 5) of cases, and all mutations are L858R mutation. In addition, we also observed that a MEC patient well-responded to EGFR TKI in the absence of EGFR mutation or amplification. These data indicate for the first time that MEC of lung is another potential target of EGFR inhibitor, and more extended clinical investigation is warranted. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN
0169-5002
Language
English
URI
http://hdl.handle.net/10371/3705
DOI
https://doi.org/10.1016/j.lungcan.2007.11.014
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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