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The accuracy of preoperative core biopsy in determining histologic grade, hormone receptors, and human epidermal growth factor receptor 2 status in invasive breast cancer

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Authors
Park, So Yeon; Kim, Ku Sang; Lee, Taek-Gu; Park, Sung-Shim; Kim, Sun Mi; Han, Wonshik; Noh, Dong-Young; Kim, Sung-Won
Issue Date
2008-02
Publisher
Elsevier
Citation
Am J Surg 2009;197:266–269
Keywords
Core biopsy; Histologic grade; Estrogen receptor; Progesterone receptor; HER-2
Abstract
Proper determination of histologic type and biomarkers in a core biopsy specimen is important before preoperative systemic therapy. The purpose of this study was to determine the accuracy of preoperative core biopsy through comparative analysis of histologic grade (HG), hormone receptors, and human epidermal growth factor receptor 2 (HER-2) status in both the core biopsy and surgical specimens. METHODS: We identified 104 patients with invasive ductal cancer who underwent core biopsy and definitive surgery in our institution. The histologic type, HG, estrogen receptor (ER), progesterone receptor (PR), and HER-2 status were determined in both the core biopsy and surgical specimens by one pathologist. RESULTS: The mean age of the 104 patients was 50 +/- 9.9 years and the mean number of core biopsies was 5.1 +/- .9. The concordance rates for histologic type, HG, ER, PR, and HER-2 status were 100%, 80.8%, 99%, 97.1%, and 86.5%, respectively. CONCLUSIONS: Core biopsy can predict histologic type, HG, ER, PR and HER-2 status preoperatively in breast cancer when used properly.
ISSN
0002-9610 (print)1879-1883 (online)
Language
English
URI
http://hdl.handle.net/10371/3709
DOI
https://doi.org/10.1016/j.amjsurg.2007.11.024
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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