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CD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: a case report
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Seol-Bong | - |
dc.contributor.author | Kim, Young A. | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.date.accessioned | 2009-05-22T08:16:00Z | - |
dc.date.available | 2009-05-22T08:16:00Z | - |
dc.date.issued | 2008-06-24 | - |
dc.identifier.citation | Pathol. Res. Pract. 204 (10) (2008) 779-783 | en |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | https://hdl.handle.net/10371/3712 | - |
dc.description.abstract | Most primary ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as conjunctival mass. A 58-year-old man presented with a palpable mass in the left lower tarsal conjunctiva incidentally detected one month previously. Histopathologic examination showed proliferation of monomorphous small-to-medium sized lymphoid cells. On immunohistochemistry, tumor cells were positive for CD20, bcl-2, and cyclin D1, and negative for CD5. PCR analysis for immunoglobulin heavy chain gene rearrangement showed monoclonal B-cell proliferation. t(11;14)(q13;q32), involving the CCND1 and IGH genes, was detected in interphase fluorescent in situ hybridization using formalin-fixed, paraffin-embedded tissue; however, MALT1 gene translocation was not observed. The final diagnosis was mantle cell lymphoma. There was no lymphadenopathy; however, bone marrow involvement of the lymphoma was suspected. The patient has been receiving systemic chemotherapy. This case emphasizes the differential diagnosis of conjunctival mantle cell lymphoma from extranodal marginal zone B-cell lymphomas of MALT regarding the clinical and pathological aspects. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Conjunctival lymphoma | en |
dc.subject | Mantle cell lymphoma | en |
dc.subject | Cyclin D1 | en |
dc.subject | t(11; 14)(q13; q32) | en |
dc.title | CD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: a case report | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 유설봉 | - |
dc.contributor.AlternativeAuthor | 김영아 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.identifier.doi | 10.1016/j.prp.2008.04.009 | - |
dc.identifier.doi | 10.1016/j.prp.2008.04.009 | - |
dc.citation.journaltitle | Pathology, research and practice | - |
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