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CD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: a case report

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dc.contributor.authorYoo, Seol-Bong-
dc.contributor.authorKim, Young A.-
dc.contributor.authorJeon, Yoon Kyung-
dc.contributor.authorKim, Chul-Woo-
dc.date.accessioned2009-05-22T08:16:00Z-
dc.date.available2009-05-22T08:16:00Z-
dc.date.issued2008-06-24-
dc.identifier.citationPathol. Res. Pract. 204 (10) (2008) 779-783en
dc.identifier.issn0344-0338-
dc.identifier.urihttps://hdl.handle.net/10371/3712-
dc.description.abstractMost primary ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as conjunctival mass. A 58-year-old man presented with a palpable mass in the left lower tarsal conjunctiva incidentally detected one month previously. Histopathologic examination showed proliferation of monomorphous small-to-medium sized lymphoid cells. On immunohistochemistry, tumor cells were positive for CD20, bcl-2, and cyclin D1, and negative for CD5. PCR analysis for immunoglobulin heavy chain gene rearrangement showed monoclonal B-cell proliferation. t(11;14)(q13;q32), involving the CCND1 and IGH genes, was detected in interphase fluorescent in situ hybridization using formalin-fixed, paraffin-embedded tissue; however, MALT1 gene translocation was not observed. The final diagnosis was mantle cell lymphoma. There was no lymphadenopathy; however, bone marrow involvement of the lymphoma was suspected. The patient has been receiving systemic chemotherapy. This case emphasizes the differential diagnosis of conjunctival mantle cell lymphoma from extranodal marginal zone B-cell lymphomas of MALT regarding the clinical and pathological aspects.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectConjunctival lymphomaen
dc.subjectMantle cell lymphomaen
dc.subjectCyclin D1en
dc.subjectt(11; 14)(q13; q32)en
dc.titleCD5-undetected by immunohistochemistry, t(11;14)(q13;q32)-positive conjunctival mantle cell lymphoma: a case reporten
dc.typeArticleen
dc.contributor.AlternativeAuthor유설봉-
dc.contributor.AlternativeAuthor김영아-
dc.contributor.AlternativeAuthor전윤경-
dc.contributor.AlternativeAuthor김철우-
dc.identifier.doi10.1016/j.prp.2008.04.009-
dc.identifier.doi10.1016/j.prp.2008.04.009-
dc.citation.journaltitlePathology, research and practice-
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