Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group

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Kim, T. M.; Lee, S. Y.; Jeon, Y. K.; Ryoo, B. Y.; Cho, G. J.; Hong, Y. S.; Kim, H. J.; Kim, S. Y.; Kim, C. S.; Kim, S.; Kim, J. S.; Sohn, S. K.; Song, H. H.; Lee, J. L.; Kang, Y. K.; Yim, C. Y.; Lee, W. S.; Yuh, Y. J.; Kim, C. W.; Heo, D. S.
Issue Date
Oxford University Press
Ann Oncol 2008; 19: 1477-1484
clinical heterogeneityNK/T-cell lymphomaprognostic factor
Background: This national survey was undertaken to propose the classification of extranodal natural killer (NK)/T-cell
lymphoma (NTCL) subtypes and to clarify a clinical heterogeneity.
Patients and methods: Two hundred and eighty patients newly diagnosed as NTCL were enrolled from 22 Korean
medical centers. Two subsets were compared: one involving the upper aerodigestive tract (UAT) and another involving
the non-upper aerodigestive tract (NUAT) region, which comprises the skin, gastrointestinal tract, and liver or soft
tissues. Clinical prognostic factors, survival outcomes, and independent predictors for survival were compared
between each subset.
Results: NUAT-NTCL (59 patients) had significantly higher proportions of disseminated disease, aggressive biologic
features, and unfavorable host reactions compared with UAT-NTCL (221 patients). NUAT-NTCL had shortened 5-year
overall survival (OS) (22% versus 41%, P = 0.001). Ann Arbor staging, the International Prognostic Index, and the NTCL
prognostic index failed to predict the OS of NUAT-NTCL, but did predict the OS in UAT-NTCL. Independent predictors
for OS by multivariate analyses differed between each subset. In the NUAT subset, extranodal sites and regional nodes
predicted the OS, while Ann Arbor staging, age, performance status, and lactate dehydrogenase level predicted the
OS in the UAT subset.
Conclusion: NUAT-NTCL may represent a distinctive disease entity in terms of clinical factors, independent
predictors, and survival outcomes.
1569-8041 (online)
0923-7534 (print)
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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