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Thiazolidinediones inhibit the growth of PC12 cells both in vitro and in vivo

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Authors
Kim, Sang Wan; Choi, Ok Kyung; Chang, Mee Soo; Shin, Chan Soo; Park, Kyong Soo; Kim, Seong Yeon
Issue Date
2008-04-29
Publisher
Elsevier
Citation
Biochem. Biophys. Res. Commun. 371 (2008) 197-202
Keywords
PC12 cells; Pheochromocytoma; PPARγ; Thiazolidinediones; Nerve growth factor
Abstract
Thiazolidinediones (TZDs) have recently been proposed as a therapy for PPARgamma-expressing tumors. Pheochromocytoma (PHEO) is associated with high morbidity and mortality due to excess catecholamine production, and few effective drug therapies currently exist. We investigated the effects of TZDs on PHEO both in vitro and in vivo. PPARgamma protein was expressed in human adrenal PHEO tissues as well as in rat PHEO cells, PC12. TZDs, including rosiglitazone (RGZ) and pioglitazone (PGZ), inhibited proliferation of PC12 cells in a dose-dependent manner and increased casapse-3 expression of PC12 cells. TZDs also reduced expression of cyclin E and cyclin-dependent kinase2. RGZ inhibited nerve growth factor-induced neurite outgrowth and reduced expression of catecholamine-synthesizing enzymes. Finally, rat PHEO growth generated by subcutaneous injection of PC12 cells was slowed in an RGZ-treated mouse. These data suggest that TZDs may be a promising therapeutic approach for medical treatment for PHEO.
ISSN
0006-291X (print)1090-2104 (online)
Language
English
URI
http://hdl.handle.net/10371/3802
DOI
https://doi.org/10.1016/j.bbrc.2008.04.035
https://doi.org/10.1016/j.bbrc.2008.04.035
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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