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Hypoxia-inducible adrenomedullin accelerates hepatocellular carcinoma cell growth

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Authors
Park, Su Cheol; Yoon, Jung-Hwan; Lee, Jeong-Hoon; Yu, Su Jong; Myung, Sun Jung; Kim, Won; Gwak, Geum-Youn; Lee, Sung-Hee; Lee, Soo-Mi; Jang, Ja Jane; Suh, Kyung-Suk; Lee, Hyo-Suk
Issue Date
2008-07-25
Publisher
Elsevier
Citation
Cancer Lett. 271 (2008) 314-322
Keywords
AdrenomedullinHypoxiaN-cadherinAktHepatocellular carcinoma
Abstract
Adrenomedullin is implicated in tumor progression and induced by hypoxia. We evaluated if adrenomedullin signaling is active in hepatocellular carcinoma (HCC), especially under hypoxic conditions, and to analyze its prognostic implication in HCC patients. HCC cells expressed adrenomedullin and its receptor, and hypoxia induced adrenomedullin expression. Adrenomedullin stimulated HCC cell growth via Akt activation, which was prevented by adrenomedullin peptide inhibitor. Clinico-pathological analysis revealed adrenomedullin extent was related to vascular invasion and N-cadherin intensity, which were reported to indicate a poor prognosis. In conclusion, adrenomedullin signaling is hypoxia-inducible and functionally active in HCCs, and its expression may be a prognostic factor.
ISSN
0304-3835 (print)
1872-7980 (online)
Language
English
URI
http://hdl.handle.net/10371/3803
DOI
https://doi.org/10.1016/j.canlet.2008.06.019

https://doi.org/10.1016/j.canlet.2008.06.019
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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