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Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Lee, Hae-Young | - |
dc.contributor.author | Na, Sang-Hoon | - |
dc.contributor.author | Chang, Sung-A | - |
dc.contributor.author | Park, Kyung-Woo | - |
dc.contributor.author | Kim, Hyung-Kwan | - |
dc.contributor.author | Kim, Song-Yi | - |
dc.contributor.author | Chang, Ho-Joon | - |
dc.contributor.author | Lee, Whal | - |
dc.contributor.author | Kang, Won Jun | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Sohn, Dae-Won | - |
dc.contributor.author | Han, Kyou-Sup | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2010-01-19T14:15:52Z | - |
dc.date.available | 2010-01-19T14:15:52Z | - |
dc.date.issued | 2006-07-06 | - |
dc.identifier.citation | Circulation. 2006 Jul 4;114(1 Suppl):I145-51. | en |
dc.identifier.issn | 1524-4539 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16820564 | - |
dc.identifier.uri | https://hdl.handle.net/10371/38231 | - |
dc.description.abstract | BACKGROUND: The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation. METHODS AND RESULTS: We randomly allocated 96 patients with myocardial infarction who underwent coronary revascularization with DES for the culprit lesion into 4 groups. Eighty-two patients completed 6-month follow-up; AMI cell infusion (n=25), AMI control (n=25), OMI cell infusion (n=16), and OMI control group (n=16). In cell infusion groups, PBSCs were mobilized by G-CSF for 3 days and delivered to infarcted myocardium via intracoronary infusion. The AMI cell infusion group showed a significant additive improvement in left ventricular ejection fraction (LVEF) and remodeling compared with controls (change of LVEF: +5.1+/-9.1% versus -0.2+/-8.6%, P<0.05; change of end-systolic volume: -5.4+/-17.0 mL versus 6.5+/-21.9 mL, P<0.05). In OMI patients, however, there was no significant change of LVEF and ventricular remodeling in spite of significant improvement of coronary flow reserve after cell infusion. G-CSF-based cell therapy did not aggravate neointimal growth with DES implantation. CONCLUSIONS: Intracoronary infusion of mobilized PBSCs with G-CSF improves LVEF and remodeling in patients with AMI but is less definite in patients with OMI. G-CSF-based stem cell therapy with DES implantation is both feasible and safe, eliminating any potential for restenosis. | en |
dc.language.iso | en | en |
dc.publisher | American Heart Association | en |
dc.subject | Acute Disease | en |
dc.subject | Aged | en |
dc.subject | Angioplasty, Transluminal, Percutaneous Coronary | en |
dc.subject | Coronary Restenosis/*prevention & control | en |
dc.subject | Coronary Vessels | en |
dc.subject | Drug Implants | en |
dc.subject | Echocardiography, Doppler, Color | en |
dc.subject | Female | en |
dc.subject | Granulocyte Colony-Stimulating Factor/pharmacology | en |
dc.subject | Hematopoietic Stem Cell Mobilization | en |
dc.subject | Humans | en |
dc.subject | Hyperplasia | en |
dc.subject | Injections, Intra-Arterial | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Magnetic Resonance Imaging, Cine | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Myocardial Infarction/pathology/*surgery | en |
dc.subject | Peripheral Blood Stem Cell Transplantation/*methods | en |
dc.subject | Stents | en |
dc.subject | Stroke Volume | en |
dc.subject | Transplantation, Autologous | en |
dc.subject | Treatment Outcome | en |
dc.subject | Tunica Intima/pathology | en |
dc.subject | Ventricular Function, Left | - |
dc.subject | Ventricular Remodeling | - |
dc.title | Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강현재 | - |
dc.contributor.AlternativeAuthor | 이해영 | - |
dc.contributor.AlternativeAuthor | 나상훈 | - |
dc.contributor.AlternativeAuthor | 장성아 | - |
dc.contributor.AlternativeAuthor | 박경우 | - |
dc.contributor.AlternativeAuthor | 김형관 | - |
dc.contributor.AlternativeAuthor | 김송이 | - |
dc.contributor.AlternativeAuthor | 장호준 | - |
dc.contributor.AlternativeAuthor | 이활 | - |
dc.contributor.AlternativeAuthor | 강원준 | - |
dc.contributor.AlternativeAuthor | 구본권 | - |
dc.contributor.AlternativeAuthor | 김용진 | - |
dc.contributor.AlternativeAuthor | 이동수 | - |
dc.contributor.AlternativeAuthor | 손대원 | - |
dc.contributor.AlternativeAuthor | 한경섭 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.105.001107 | - |
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