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Young age is independent prognostic factor for cancer-specific survival of low-stage clear cell renal cell carcinoma

Cited 31 time in Web of Science Cited 30 time in Scopus
Authors
Jung, Eun-Jung; Lee, Hyun Ju; Kwak, Cheol; Ku, Ja Hyeon; Moon, Kyung Chul
Issue Date
2008-03-11
Publisher
Elsevier
Citation
Urology. 2009;73:137-141
Abstract
OBJECTIVES: To clarify the clinicopathologic features and prognosis of renal cell carcinoma (RCC) in young adults. The features of RCC in young adults have been reported, but the results have been conflicting. METHODS: The data from 619 patients with RCC were analyzed. The patients were divided into 2 groups according to age at diagnosis, 55 years of age. The clinicopathologic parameters were compared, and a survival analysis was performed. RESULTS: Younger patients were more likely to have a lower disease stage (P < .001), lower nuclear grade (P = .018), and smaller tumor size (P = .005) and a greater 5-year cancer-specific survival rate (P < .001) than older patients. Young age was a favorable prognostic factor for cancer-specific survival of clear cell RCC (P < .001). On multivariate analysis, young age was independently associated with a longer cancer-specific survival rate of clear cell RCC (P = .003). In addition, the prognostic implication of age differed between low (I or II) and high (III or IV) stage tumors. In low-stage clear cell RCC, young age was significantly associated with prolonged cancer-specific survival on univariate (P < .001) and multivariate (P = .007) analyses, but not in high-stage clear cell RCC (P = .906). CONCLUSIONS: RCC in patients <55 years presented with a lower stage, lower nuclear grade, and smaller size than did the older patients. Young age was an independent prognostic factor for cancer-specific survival of low-stage clear cell RCC.
ISSN
1527-9995 (online)
0090-4295 (print)
Language
English
URI
http://hdl.handle.net/10371/3874
DOI
https://doi.org/10.1016/j.urology.2008.08.460

https://doi.org/10.1016/j.urology.2008.08.460
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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