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Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses

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Authors
Tang, Choon Kit; Sheng, Kuo-Ching; Pouniotis, Dodie; Esparon, Sandra; Son, Hye-Youn; Kim, Chul-Woo; Pietersz, Geoffrey A.; Apostolopoulos, Vasso
Issue Date
2008-05-22
Publisher
Elsevier
Citation
Vaccine 2008;26(31):3827-34
Keywords
DNA; Vaccines; Gene delivery; Mannan; MUC1
Abstract
DNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to generate potent immune responses in mice. Herein, we further investigated the suitability of OMPLL and RMPLL as carriers for mucin 1 (MUC1) DNA vaccination for cancer immunotherapy. Studies presented here showed that immune responses in C57BL/6 mice induced by OMPLL-MUC1 DNA and RMPLL-MUC1 DNA immunization were more immunogenic compared to MUC1 DNA alone. Moreover, tumor protection was evident at a dose as low as 0.5 microg. In addition, strong T cell responses were induced in HLA-A2 transgenic and human MUC1 transgenic mice. These results demonstrate the potential of OM and RM as efficient non-viral gene delivery carriers for DNA vaccines for use in cancer immunotherapy.
ISSN
0264-410X
Language
English
URI
http://www.elsevier.com/locate/vaccine
http://hdl.handle.net/10371/3889
DOI
https://doi.org/10.1016/j.vaccine.2008.05.008
https://doi.org/10.1016/j.vaccine.2008.05.008
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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