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Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses
DC Field | Value | Language |
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dc.contributor.author | Tang, Choon Kit | - |
dc.contributor.author | Sheng, Kuo-Ching | - |
dc.contributor.author | Pouniotis, Dodie | - |
dc.contributor.author | Esparon, Sandra | - |
dc.contributor.author | Son, Hye-Youn | - |
dc.contributor.author | Kim, Chul-Woo | - |
dc.contributor.author | Pietersz, Geoffrey A. | - |
dc.contributor.author | Apostolopoulos, Vasso | - |
dc.date.accessioned | 2009-05-27T01:08:52Z | - |
dc.date.available | 2009-05-27T01:08:52Z | - |
dc.date.issued | 2008-05-22 | - |
dc.identifier.citation | Vaccine 2008;26(31):3827-34 | en |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://www.elsevier.com/locate/vaccine | - |
dc.identifier.uri | https://hdl.handle.net/10371/3889 | - |
dc.description.abstract | DNA immunization is an attractive form of vaccination, which has shown promising results only in small animal models. There is a need to develop efficient gene delivery systems. We previously demonstrated that oxidized (OM) and reduced mannan (RM) complexed to ovalbumin DNA via poly-l-lysine (PLL), were able to generate potent immune responses in mice. Herein, we further investigated the suitability of OMPLL and RMPLL as carriers for mucin 1 (MUC1) DNA vaccination for cancer immunotherapy. Studies presented here showed that immune responses in C57BL/6 mice induced by OMPLL-MUC1 DNA and RMPLL-MUC1 DNA immunization were more immunogenic compared to MUC1 DNA alone. Moreover, tumor protection was evident at a dose as low as 0.5 microg. In addition, strong T cell responses were induced in HLA-A2 transgenic and human MUC1 transgenic mice. These results demonstrate the potential of OM and RM as efficient non-viral gene delivery carriers for DNA vaccines for use in cancer immunotherapy. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | DNA | en |
dc.subject | Vaccines | en |
dc.subject | Gene delivery | en |
dc.subject | Mannan | en |
dc.subject | MUC1 | en |
dc.title | Oxidized and reduced mannan mediated MUC1 DNA immunization induce effective anti-tumor responses | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 손혜연 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.identifier.doi | 10.1016/j.vaccine.2008.05.008 | - |
dc.citation.journaltitle | Vaccine | - |
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