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High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer

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Authors
Kim, D-W; Min, HS; Lee, K-H; Kim, YJ; Oh, D-Y; Jeon, YK; Lee, S-H; Im, S-A; Chung, DH; Kim, YT; Kim, T-Y; Bang, Y-J; Sung, SW; Kim, JH; Heo, DS
Issue Date
2008-02-19
Publisher
Nature Publishing Group
Citation
Br J Cancer 98:1118-1124 (2008) 98, 1118–1124
Keywords
macrophage; non-small cell lung cancer; epidermal growth factor receptor; survival analysis
Abstract
The purpose of this study was to investigate the prognostic value of tumour-associated macrophages with a focus on micro-anatomical localisation and determine whether molecular changes of the epidermal growth factor receptor (EGFR) are related to macrophage infiltration in resected non-small cell lung cancer (NSCLC). One hundred and forty-four patients were included in this study. Immunohistochemistry was used to identify CD68+ macrophages in the tumour islet and surrounding stroma. Epidermal growth factor receptor mutations were studied by direct sequencing. The EGFR gene copy number and protein expression were analysed by fluorescence in situ hybridisation and immunohistochemistry. Patients with a high tumour islet macrophage density survived longer than did the patient with a low tumour islet macrophage density (5-year overall survival rate was 63.9 vs 38.9%, P=0.0002). A multivariate Cox proportional hazard analysis revealed that the tumour islet macrophage count was an independent prognostic factor for survival (hazard ratio 0.471, 95% confidence interval 0.300-0.740). However, EGFR mutations, gene copy number, and protein expression were not related to the macrophage infiltration. In conclusion, tumour islet macrophage infiltration was identified as a strong favourable independent prognostic marker for survival but not correlated with the molecular changes of the EGFR in patients with resected NSCLC.
ISSN
0007-0920 (print)1532-1827 (online)
Language
English
URI
http://www.bjcancer.com
http://hdl.handle.net/10371/3900
DOI
https://doi.org/10.1038/sj.bjc.6604256
https://doi.org/10.1038/sj.bjc.6604256
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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