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Expression of Bcl-2 in olfactory neuroblastoma and its association with chemotherapy and survival
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong-Whun | - |
dc.contributor.author | Kong, Il Gyu | - |
dc.contributor.author | Lee, Chul Hee | - |
dc.contributor.author | Kim, Dong Young | - |
dc.contributor.author | Rhee, Chae-Seo | - |
dc.contributor.author | Min, Yang-Gi | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.date.accessioned | 2009-05-27T04:31:09Z | - |
dc.date.available | 2009-05-27T04:31:09Z | - |
dc.date.issued | 2008-11-07 | - |
dc.identifier.citation | Otolaryngol Head Neck Surg 2008;139:708-12 | en |
dc.identifier.issn | 0194-5998 | - |
dc.identifier.uri | https://hdl.handle.net/10371/3915 | - |
dc.description.abstract | This study aimed to identify the prognostic value of tumor markers in olfactory neuroblastoma (ONB). STUDY DESIGN AND SETTING: Seventeen patients with ONB (23 tumor specimens) were included. Each specimen was studied for bcl-2, p53, MIC-2 by immunohistochemistry and for N-myc by chromogenic in situ hybridization. RESULTS: Twelve (70%) of 17 patients and 15 (65%) of 23 specimens showed positive reactivity for bcl-2. Of seven patients who were treated with neoadjuvant chemotherapy, one patient with diffuse bcl-2 expression achieved complete remission. Another patient without bcl-2 expression had no response to chemotherapy. Five patients who showed partial positivity achieved partial remission. Survival and bcl-2 expression tended to correlate, but it was not statistically significant (P = 0.06). All of the ONB specimens were negative for N-myc. Positive immunoreactivity for MIC-2 or p53 was found only in one specimen. CONCLUSION: Bcl-2 expression was commonly found in ONB and the immunoreactivity for bcl-2 might predict response to neoadjuvant chemotherapy. In addition, Bcl-2 expression tended to be associated with worse survival. | en |
dc.description.sponsorship | This work was partly supported by SNUBH grants 06-2007-028 and 02-2007-035. | en |
dc.language.iso | en | en |
dc.publisher | American Academy of Otolaryngology–Head and Neck | en |
dc.publisher | Elsevier | - |
dc.title | Expression of Bcl-2 in olfactory neuroblastoma and its association with chemotherapy and survival | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 공일규 | - |
dc.contributor.AlternativeAuthor | 이철희 | - |
dc.contributor.AlternativeAuthor | 김동영 | - |
dc.contributor.AlternativeAuthor | 리채서 | - |
dc.contributor.AlternativeAuthor | 민양기 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.contributor.AlternativeAuthor | 정진행 | - |
dc.identifier.doi | 10.1016/j.otohns.2008.03.011 | - |
dc.citation.journaltitle | Otolaryngology and head and neck surgery | - |
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