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High correlations between primary tumours and loco-regional metastatic lymph nodes in non-small-cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2-F18-fluoro-D-glucose uptake

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Authors
Nguyen, Xuan Canh; So, Young; Chung, Jin-Haeng; Lee, Won Woo; Park, So Yeon; Kim, Sang Eun
Issue Date
2008-03-07
Publisher
Elsevier
Citation
Eur J Cancer 2008;44:692-8
Keywords
Non-small-cell lung cancer; FDG-PET; Lymph node; Glucose transporter
Abstract
The purpose of the study was to investigate whether glucose transporter type 1 (Glut-1) mediated 2-deoxy-2-F18-fluoro-D-glucose (FDG) uptake of primary tumour is related to the likelihood of malignancy involvement in loco-regional lymph nodes (LNs) in 126 non-small-cell lung cancer (NSCLC) patients (M:F=103:23, age=65+/-9.7 years). Maximum standardised uptake values (maxSUV) and Glut-1 expression levels (determined by PET and immunostaining, respectively) of primary tumours and PET positive loco-regional LNs were compared. Significant correlations were found between malignant LNs and primary tumours with respect to maxSUV (r=0.6451, p<0.0001), %Glut-1 expression (r=0.8341, p<0.0001) and Glut-1 staining intensity (rho=0.827, p<0.0001). The area-under-curve value for LN differentiation using lymph node maxSUV was significantly higher in patients with a primary tumour maxSUV of >6 (AUC=0.775, p=0.0001). High correlations between the primary tumours and metastatic LNs in NSCLC with respect to the Glut-1 mediated FDG uptake may be useful for mediastinal LN discrimination by FDG-PET.
ISSN
0959-8049 (print)1879-0852 (online)
Language
English
URI
http://hdl.handle.net/10371/3932
DOI
https://doi.org/10.1016/j.ejca.2008.02.009
https://doi.org/10.1016/j.ejca.2008.02.009
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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