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Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells

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dc.contributor.authorPhi, Ji Hoon-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorChae, Jong Hee-
dc.contributor.authorHong, Ki Ho-
dc.contributor.authorPark, Sung Sup-
dc.contributor.authorKang, Ji Hyun-
dc.contributor.authorJun, Jong Kwan-
dc.contributor.authorCho, Byung-Kyu-
dc.contributor.authorWang, Kyu-Chang-
dc.contributor.authorKim, Seung-Ki-
dc.date.accessioned2009-05-27T22:51:54Z-
dc.date.available2009-05-27T22:51:54Z-
dc.date.issued2008-07-16-
dc.identifier.citationChilds Nerv Syst 24:1499-1503en
dc.identifier.issn0256-7040 (print)-
dc.identifier.issn1433-0350 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/3960-
dc.description.abstractCongenital Subependymal giant cell astrocytoma (SEGA), diagnosed in fetal and neonatal period, is extremely rare. Previous studies have reported poor surgical outcomes of this small group of patients. We encountered a patient diagnosed as congenital SEGA and report the surgical outcome along with interesting immuno-phenotypes of giant tumor cells. CASE: Ventriculomegaly and a hypoechoic mass near the foramen of Monro were detected in a fetus on prenatal ultrasonography in the 35th week of gestation. Surgery was scheduled 2 months later to reduce the risk of operative complications. At postnatal 2 months, gross total resection of the tumor was achieved without complications. The patient had been followed up for 1 year without tumor recurrence. In double immunofluorescence, the prototype cells of SEGA expressed a variety of neural stem cell (nestin and Sox2) and radial glial cell markers (vimentin and brain lipid-binding protein), in addition to glutamate/aspartate transporter and glial fibrillary acidic protein. CONCLUSIONS: Congenital SEGA can be successfully treated with judicious use of observation period and careful evaluation of general conditions. Pathological findings support the concept that SEGA may originate from aberrant radial glial cells in the developing brain.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectSubependymal giant cell astrocytomaen
dc.subjectCongenitalen
dc.subjectTuberous sclerosis complexen
dc.subjectRadial glial cellen
dc.titleCongenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor피지훈-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor채종희-
dc.contributor.AlternativeAuthor홍기호-
dc.contributor.AlternativeAuthor박성섭-
dc.contributor.AlternativeAuthor강지현-
dc.contributor.AlternativeAuthor전종관-
dc.contributor.AlternativeAuthor조병규-
dc.contributor.AlternativeAuthor왕규창-
dc.contributor.AlternativeAuthor김승기-
dc.identifier.doi10.1007/s00381-008-0681-x-
dc.citation.journaltitleChild's nervous system : ChNS-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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