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Putative association of peroxisome proliferator-activated receptor gamma co-activator 1beta (PPARGC1B) polymorphism with Type 2 diabetes mellitus

Cited 10 time in Web of Science Cited 10 time in Scopus
Authors
Park, K S; Shin, H D; Park, B L; Cheong, H S; Cho, Y M; Lee, H K; Lee, J-Y; Lee, J-K; Kim, H Tae; Park, C-S; Han, B G; Kimm, K; Oh, B
Issue Date
2006-06-09
Publisher
Wiley-Blackwell
Citation
Diabet Med. 2006 Jun;23(6):635-42.
Keywords
Asian Continental Ancestry GroupBase SequenceCarrier Proteins/*geneticsCase-Control StudiesDiabetes Mellitus, Type 2/ethnology/*genetics/metabolismExonsGene FrequencyGenetic MarkersGenetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceKoreaLogistic ModelsMolecular Sequence DataPolymorphism, GeneticPolymorphism, Single Nucleotide
Abstract
AIMS: Peroxisome proliferator-activated receptor gamma co-activator 1beta (PPARGC1B) may play an important role in obesity and Type 2 diabetes mellitus (T2DM). In an effort to identify genetic polymorphisms in potential candidate genes for T2DM, genetic associations of PPARGC1B were examined in a Korean T2DM study. METHODS: We have sequenced the PPARGC1B, and examined its association with T2DM and diabetic phenotypes in a Korean T2DM study (775 T2DM patients and 316 control subjects) using the TaqMan method. Logistic and multiple regression models were employed to analyse the genetic contributions of polymorphisms. Nineteen polymorphisms were identified in PPARGC1B. RESULTS: By logistic regression analysis controlling for age and sex as covariates, one non-synonymous single-nucleotide polymorphism (SNP; +102605C>A; Arg292Ser) in exon 5 showed marginal significant associations with the risk of T2DM. The allele frequency of the minor allele ['A (= Ser)' allele of +102605C>A] was lower among T2DM patients (frequency = 0.101) than among control subjects (frequency = 0.135) [P = 0.03, OR = 0.71 (95% CI: 0.51-0.94)]. Furthermore, serum triglyceride level was also associated with this non-synonymous SNP (+102605C>A; Arg292Ser) in exon 5 among controls (P = 0.03 in the dominant analysing model). Serum triglyceride levels [1.46 +/- 0.70 (log-transformed value; 0.12 +/- 0.18)] were lower in individuals who carry one or two copies of minor alleles than among others [1.60 +/- 0.85 (log-transformed value; 0.16 +/- 0.21)]. CONCLUSION: The present study provides, for the first time, information about genetic polymorphisms in PPARGC1B and putative associations of one non-synonymous SNP with the risk of T2DM and serum triglyceride (TG) levels in the Korean population, although this result was not significant after correction for multiple testing.
ISSN
0742-3071 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16759305

http://hdl.handle.net/10371/44040
DOI
https://doi.org/10.1111/j.1464-5491.2006.01882.x
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College of Medicine/School of Medicine (의과대학/대학원)Molecular and Genomic Medicine (분자유전체의학전공)Journal Papers (저널논문_분자유전체의학전공)
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