S-Space College of Medicine/School of Medicine (의과대학/대학원) Molecular and Genomic Medicine (분자유전체의학전공) Journal Papers (저널논문_분자유전체의학전공)
Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals
- Shin, H D; Park, K S; Park, B L; Cheong, H S; Cho, Y M; Lee, H K; Lee, J-Y; Lee, J-K; Kim, H T; Han, B G; Kim, J W; Koh, I; Kim, Y J; Oh, B; Kimm, K; Park, C
- Issue Date
- Diabet Med. 2006 Jan;23(1):72-6.
- Antigens, CD14/*genetics; Base Sequence; *Body Mass Index; Diabetes Mellitus, Type 2/genetics; Exons/genetics; Female; Gene Frequency/genetics; Genotype; Humans; Introns/genetics; Male; Middle Aged; Polymorphism, Genetic/*genetics; Polymorphism, Single Nucleotide/genetics; Promoter Regions, Genetic/*genetics; Triglycerides/*blood
- AIMS: Growing evidence supports the hypothesis that chronic low-grade inflammation related to innate immunity may play an important role in the pathophysiology of Type 2 diabetes mellitus (T2DM). The monocyte differentiation antigen CD14 gene (CD14) acts as the receptor for lipopolysaccharide (LPS) and augments monocyte/macrophage inflammatory responses. METHODS: We have sequenced the gene, including all exons, exon/intron boundaries, and the -1.5 kb of the 5' flanking region. Two common loci (minor allele frequency > 0.05) were genotyped in 775 T2DM patients and 316 control subjects recruited in the Korean T2DM Study. RESULTS: Eight polymorphisms, including four non-synonymous forms, were identified in CD14. No polymorphisms were found in association with T2DM. However, one common promoter SNP (-260T>C) was significantly associated with both the serum triglyceride level (TG) and body mass index (BMI) in non-diabetic control subjects. Individuals who carried the minor allele (C) had higher TG levels (1.65 +/- 0.81 vs. 1.46 +/- 0.80 mmol/l; P = 0.0007) and BMI (23.96 +/- 3.00 vs. 23.28 +/- 3.22 kg/m(2); P = 0.04) as compared with subjects carrying T/T genotypes. CONCLUSION: Our data suggest that lipid metabolism and obesity, important pathophysiological elements of T2DM and the metabolic syndrome, are regulated by complex mechanisms that include the CD14 gene polymorphism-mediated genetic propensity to non-specific inflammatory responses.
- 0742-3071 (Print)
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