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Atelectasis Induced by Thoracotomy Causes Lung Injury during Mechanical Ventilation in Endotoxemic Rats

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Authors
Choi, Won-Il; Kwon, Kun Young; Kim, Jin Mo; Deborah A., Quinn; Charles A., Hales; Seo, Jeong Wook
Issue Date
2008
Publisher
대한의학회 = Korean Academy of Medical Science
Citation
J Korean Med Sci 2008; 23: 406-13
Keywords
Atelectasis; Functional Residual Capacity; Lung Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Inhibitor
Abstract
Atelectasis can impair arterial oxygenation and decrease lung compliance. However,
the effects of atelectasis on endotoxemic lungs during ventilation have not been well
studied. We hypothesized that ventilation at low volumes below functional residual
capacity (FRC) would accentuate lung injury in lipopolysaccharide (LPS)-pretreated
rats. LPS-pretreated rats were ventilated with room air at 85 breaths/min for 2 hr
at a tidal volume of 10 mL/kg with or without thoracotomy. Positive end-expiratory
pressure (PEEP) was applied to restore FRC in the thoracotomy group. While LPS
or thoracotomy alone did not cause significant injury, the combination of endotoxemia
and thoracotomy caused significant hypoxemia and hypercapnia. The injury
was observed along with a marked accumulation of inflammatory cells in the interstitium
of the lungs, predominantly comprising neutrophils and mononuclear cells.
Immunohistochemistry showed increased inducible nitric oxide synthase (iNOS)
expression in mononuclear cells accumulated in the interstitium in the injury group.
Pretreatment with PEEP or an iNOS inhibitor (1400 W) attenuated hypoxemia, hypercapnia,
and the accumulation of inflammatory cells in the lung. In conclusion, the
data suggest that atelectasis induced by thoracotomy causes lung injury during
mechanical ventilation in endotoxemic rats through iNOS expression.
ISSN
1011-8934 (print)1598-6357 (online)
Language
English
URI
http://hdl.handle.net/10371/4494
DOI
https://doi.org/10.3346/jkms.2008.23.3.406
https://doi.org/10.3346/jkms.2008.23.3.406
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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