SHERP

# Role of Type II NKT Cells in the Suppression of Graft-versus-Host Disease

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Oh, Sae Jin; Kim, Ji Hyung; Min, Chang Ki; Chung, Doo Hyun
Issue Date
2008
Publisher
Begell House
Citation
Crit Rev Immunol. 2008;28(3):249-67
Abstract
Natural killer T (NKT) cells, a distinct subset of T cells that recognize glycolipids on CD1d molecules, express both TCR and NK receptors and are critical in regulating various immune responses by modulating the Th1/Th2 balance. Upon activation, NKT cells produce large amounts of IL-4 and IFN-gamma, resulting in the enhancement or inhibition of immune responses. Recent studies have shown that NKT cells are heterogeneous in terms of the expression of a specific Valpha chain of TCR (Valpha14-Jalpha18 in mice and Valpha24-JalphaQ in humans) and reactivity against the glycolipid alpha-galactosylceramide (alpha-GalCer). Accordingly, NKT cells are classified into type I (invariant) and type II (non-invariant) cells in mice and humans. Although the functional roles of type I NKT cells are well characterized in various immune diseases, little is known regarding the function of type II NKT cells. Recent study has demonstrated that type II NKT cells in donor bone marrow play protective roles in graft-versus-host disease (GVHD), in which the complicated immunologic processes are involved. In this review, we discuss the pathogenesis of GVHD and the distinct functions of type II NKT cells in the development of GVHD.
ISSN
1040-8401
Language
English
URI
http://www.begellhouse.com/journals/2ff21abf44b19838,3ed160d861dcd321,38d7706b18b39a0b.html
http://hdl.handle.net/10371/4553
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse