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Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells

Cited 39 time in Web of Science Cited 39 time in Scopus
Authors
Shin, Jin-Young; Yoon, Il-Hee; Kim, Jung-Sik; Kim, Bongi; Park, Chung-Gyu
Issue Date
2009-03-03
Publisher
Elsevier
Citation
Cell Immunol. 2009;256(1-2):72-8. Epub 2009 Feb 26.
Keywords
AnimalsBase SequenceCell LineCell Proliferation/drug effectsChemotaxis, Leukocyte/*drug effectsDNA Primers/geneticsHumansImmunologic Factors/*pharmacologyImmunotherapyInterferon-gamma/biosynthesisInterleukin-10/*biosynthesisLymphocyte ActivationMaleMiceMice, Inbred C57BLModels, ImmunologicalNeoplasms/immunology/therapyRNA, Messenger/genetics/metabolismT-Lymphocytes/cytology/*drug effects/*immunology/physiologyVascular Endothelial Growth Factor A/*pharmacologyVascular Endothelial Growth Factor Receptor-1/genetics/metabolismVascular Endothelial Growth Factor Receptor-2/genetics/metabolism
Abstract
Vascular endothelial growth factor (VEGF) is a proangiogenic mediator that promotes tumor growth. The role of VEGF in T lymphocytes is unknown. We found that T lymphocytes activated by either anti-CD3 monoclonal antibody (mAb) plus anti-CD28 mAb or by antigens on antigen-presenting cells transcribed mRNA for VEGF receptor 1 (VEGFR1) and VEGFR2. However, only VEGFR1 was expressed on the T cell surface. The addition of VEGF to either resting or activated T cells did not affect their proliferation, but VEGF increased IL-10 production and slightly decreased IFN-gamma production. A chemotaxis assay revealed that activated T lymphocytes migrate in response to VEGF. Our data suggest that VEGF has a direct immunomodulatory effect on T cells. Engagement of a high concentration of VEGF with VEGFR1 on T cells may cause T cells to migrate to tumor sites, and this interaction may play a role in IL-10-mediated immune evasion by tumor cells.
ISSN
1090-2163 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19249018

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WCF-4VPKR11-1-F&_cdi=6737&_user=168665&_orig=search&_coverDate=12%2F31%2F2009&_sk=997439998&view=c&wchp=dGLzVlz-zSkWz&md5=99df80e79fabe114129a727e1a4eee20&ie=/sdarticle.pdf

http://hdl.handle.net/10371/45973
DOI
https://doi.org/10.1016/j.cellimm.2009.01.006
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College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
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