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Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Jin-Young | - |
dc.contributor.author | Yoon, Il-Hee | - |
dc.contributor.author | Kim, Jung-Sik | - |
dc.contributor.author | Kim, Bongi | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.date.accessioned | 2010-01-28T01:28:43Z | - |
dc.date.available | 2010-01-28T01:28:43Z | - |
dc.date.issued | 2009-03-03 | - |
dc.identifier.citation | Cell Immunol. 2009;256(1-2):72-8. Epub 2009 Feb 26. | en |
dc.identifier.issn | 1090-2163 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19249018 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WCF-4VPKR11-1-F&_cdi=6737&_user=168665&_orig=search&_coverDate=12%2F31%2F2009&_sk=997439998&view=c&wchp=dGLzVlz-zSkWz&md5=99df80e79fabe114129a727e1a4eee20&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/45973 | - |
dc.description.abstract | Vascular endothelial growth factor (VEGF) is a proangiogenic mediator that promotes tumor growth. The role of VEGF in T lymphocytes is unknown. We found that T lymphocytes activated by either anti-CD3 monoclonal antibody (mAb) plus anti-CD28 mAb or by antigens on antigen-presenting cells transcribed mRNA for VEGF receptor 1 (VEGFR1) and VEGFR2. However, only VEGFR1 was expressed on the T cell surface. The addition of VEGF to either resting or activated T cells did not affect their proliferation, but VEGF increased IL-10 production and slightly decreased IFN-gamma production. A chemotaxis assay revealed that activated T lymphocytes migrate in response to VEGF. Our data suggest that VEGF has a direct immunomodulatory effect on T cells. Engagement of a high concentration of VEGF with VEGFR1 on T cells may cause T cells to migrate to tumor sites, and this interaction may play a role in IL-10-mediated immune evasion by tumor cells. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Base Sequence | en |
dc.subject | Cell Line | en |
dc.subject | Cell Proliferation/drug effects | en |
dc.subject | Chemotaxis, Leukocyte/*drug effects | en |
dc.subject | DNA Primers/genetics | en |
dc.subject | Humans | en |
dc.subject | Immunologic Factors/*pharmacology | en |
dc.subject | Immunotherapy | en |
dc.subject | Interferon-gamma/biosynthesis | en |
dc.subject | Interleukin-10/*biosynthesis | en |
dc.subject | Lymphocyte Activation | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Models, Immunological | en |
dc.subject | Neoplasms/immunology/therapy | en |
dc.subject | RNA, Messenger/genetics/metabolism | en |
dc.subject | T-Lymphocytes/cytology/*drug effects/*immunology/physiology | en |
dc.subject | Vascular Endothelial Growth Factor A/*pharmacology | en |
dc.subject | Vascular Endothelial Growth Factor Receptor-1/genetics/metabolism | en |
dc.subject | Vascular Endothelial Growth Factor Receptor-2/genetics/metabolism | en |
dc.title | Vascular endothelial growth factor-induced chemotaxis and IL-10 from T cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신진영 | - |
dc.contributor.AlternativeAuthor | 윤일희 | - |
dc.contributor.AlternativeAuthor | 김정식 | - |
dc.contributor.AlternativeAuthor | 김봉기 | - |
dc.contributor.AlternativeAuthor | 박정규 | - |
dc.identifier.doi | 10.1016/j.cellimm.2009.01.006 | - |
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