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Treatment outcomes for radiotherapy alone are comparable with neoadjuvant chemotherapy followed by radiotherapy in early-stage nasopharyngeal carcinoma

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dc.contributor.authorSong, Chang Hoon-
dc.contributor.authorWu, Hong-Gyun-
dc.contributor.authorHeo, Dae Seog-
dc.contributor.authorKim, Kwang Hyun-
dc.contributor.authorSung, Myung-Whun-
dc.contributor.authorPark, Charn Il-
dc.date.accessioned2010-01-28T08:17:07Z-
dc.date.available2010-01-28T08:17:07Z-
dc.date.issued2008-01-25-
dc.identifier.citationLaryngoscope. 2008 Apr;118(4):663-70.en
dc.identifier.issn0023-852X (Print)-
dc.identifier.issn0023-852X (Linking)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18216741-
dc.identifier.urihttps://hdl.handle.net/10371/46302-
dc.description.abstractOBJECTIVES: To analyze the impact of neoadjuvant chemotherapy (CT) on the treatment of early-stage nasopharyngeal carcinoma (NPC) as compared with radiotherapy (RT) alone. METHODS: We analyzed retrospectively the outcome of 60 previously untreated and histologically confirmed early-stage NPC patients treated with either RT alone or with neoadjuvant CT followed by RT (CT/RT) at the Seoul National University Hospital between 1986 and 2004. Neoadjuvant CT consisted of three cycles with 5-fluourouracil and cisplatin. RT was given to the nasopharynx and neck nodes. The median dose to the primary site, involved nodes, and elective nodes was 70.2 Gy, 63 Gy, and 45 Gy, respectively. According to the 1997 American Joint Committee on Cancer staging system, 9 patients had stage I or IIA disease, and 22 patients had stage IIB disease in the RT group. For the CT/RT group, 8 patients had stage I or IIA disease, and 21 patients had stage IIB disease. The median follow-up for all patients was 124.5 (range, 5-239) months. RESULTS: The 5-year locoregional failure-free (LRFF), distant metastasis-free (DMF), disease-free survival (DFS), and overall survival (OS) rate was 84%, 93%, 81%, and 84% for the RT group and 77%, 86%, 71%, and 79% for the CT/RT group, respectively. There were no significant differences in LRFF (P = .728), DMF (P = .433), DFS (P = .562), and OS (P = .625) rates between the RT and CT/RT groups. Multivariate analysis revealed that delaying RT for more than 81 days was significantly associated with an increased risk of locoregional failure in the subgroup of patients with stage IIB disease (P = .044). CONCLUSIONS: In our retrospective analysis, the use of neoadjuvant CT showed no additional benefit to treatment with RT alone. Neoadjuvant CT may cause deleterious effect on stage IIB disease by delaying RT.en
dc.language.isoenen
dc.publisherLaryngoscopeen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntimetabolites, Antineoplastic/administration & dosageen
dc.subjectAntineoplastic Agents/administration & dosageen
dc.subjectAntineoplastic Combined Chemotherapy Protocols/therapeutic useen
dc.subjectCarcinoma/drug therapy/*radiotherapyen
dc.subjectCarcinoma, Squamous Cell/drug therapy/radiotherapyen
dc.subjectChilden
dc.subjectCisplatin/administration & dosageen
dc.subjectDisease-Free Survivalen
dc.subjectFemaleen
dc.subjectFluorouracil/administration & dosageen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectLymph Nodes/radiation effectsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNasopharyngeal Neoplasms/drug therapy/*radiotherapyen
dc.subjectNeoplasm Recurrence, Local/pathologyen
dc.subjectNeoplasm Stagingen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Rateen
dc.subjectTreatment Outcomeen
dc.subjectNeoadjuvant Therapy-
dc.titleTreatment outcomes for radiotherapy alone are comparable with neoadjuvant chemotherapy followed by radiotherapy in early-stage nasopharyngeal carcinomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor송창훈-
dc.contributor.AlternativeAuthor우홍균-
dc.contributor.AlternativeAuthor허대석-
dc.contributor.AlternativeAuthor김광현-
dc.contributor.AlternativeAuthor성명훈-
dc.contributor.AlternativeAuthor박찬일-
dc.identifier.doi10.1097/MLG.0b013e3181626cfe-
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