S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Hepatitis a in Korea: epidemiological shift and call for vaccine strategy
- Lee, Donghun; Cho, Young-Ae; Park, Youngsoo; Hwang, Jin-Hyuk; Kim, Jin Wook; Kim, Na Young; Lee, Dong Ho; Lee, Wonwoo; Jeong, Sook-Hyang
- Issue Date
- Intervirology. 2008;51(2):70-4. Epub 2008 Apr 22.
- Adolescent; Adult; Child; Child, Preschool; Female; Hepatitis A/*epidemiology/physiopathology/prevention & control; Hepatitis A Antibodies/*blood; Hepatitis A Vaccines/administration & dosage; Hepatitis A Virus, Human/*immunology; Hospitalization; Humans; Infant; Korea/epidemiology; Male; Middle Aged; Severity of Illness Index; Vaccination
- OBJECTIVE: The number of adult hepatitis A cases has progressively been increasing during the last several years in Korea. The aim of the present study was to describe the recent clinical features of hepatitis A and the seroprevalence of hepatitis A virus (HAV), and to discuss HAV vaccine strategy in Korea. METHODS: Retrospective analysis of clinical characteristics of hepatitis A from 109 patients consecutively enrolled at a community hospital between 2003 and 2006 as well as cross-sectional study of seroprevalence of HAV from 307 patients of hospital population group during the same period were performed. RESULTS: Most hepatitis A cases were young adults in their twenties or thirties, and the severity of the disease was related to the age of patients. The seroprevalence of HAV was 62%, which was dependent on the age of patients. HAV seroepidemiology in Korea is rapidly changing and a growing number of young adults are susceptible to HAV infection. CONCLUSIONS: The clinical features and the epidemiological shift of HAV urge Korea, as well as other countries which are experiencing similar issues, to promote childhood vaccination and consider catch-up vaccination for adolescents and young adults.
- 1423-0100 (Electronic)
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