Publications
Detailed Information
Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hye-Ja | - |
dc.contributor.author | Ryu, Ha-Jung | - |
dc.contributor.author | Shin, Hyoung-Doo | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Kim, Jong Yeol | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Song, Jihyun | - |
dc.contributor.author | Oh, Bermseok | - |
dc.date.accessioned | 2010-01-29 | - |
dc.date.available | 2010-01-29 | - |
dc.date.issued | 2008-08-30 | - |
dc.identifier.citation | Clin Chim Acta. 2008 Dec;398(1-2):27-33. Epub 2008 Aug 5. | en |
dc.identifier.issn | 0009-8981 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18755175 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T57-4T4XRD0-2-8&_cdi=4995&_user=168665&_orig=search&_coverDate=12%2F31%2F2008&_sk=996019998&view=c&wchp=dGLbVzb-zSkzS&md5=f05b4e38f9f79e4d6c6f71acbc64d81c&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/46578 | - |
dc.description.abstract | BACKGROUND: Mitochondrial uncoupling proteins (UCPs) are considered pivotal regulators of energy and glucose homeostasis. We examined the effect of 23 single nucleotide polymorphisms (SNPs) in the UCP genes on type 2 diabetes mellitus (T2DM) and related phenotypes to identify genetic factors that may be involved in susceptibility to T2DM. METHODS: We directly sequenced the coding region, portions of the 5'- and 3'-flanking sequences, and the intron-exon boundaries of the UCP genes from 24 individuals. We genotyped 23 SNPs in 761 unrelated patients with T2DM and 632 unrelated non-diabetic control subjects and investigated their potential involvement in T2DM. RESULTS: We identified association between T2DM and the following 3 SNPs in UCP2: UCP2 -5331G>A (P=0.018, odds ratio (OR)=1.38, 95% CI (confidence interval)=1.06-1.79), UCP2 -3998C>G (P=0.021, OR=1.37, 95% CI=1.05-1.78), and UCP2 +320C>T (P=0.019, OR=0.73, 95% CI=0.57-0.95). There was strong linkage disequilibrium (LD) among these 3 SNPs (r2=0.94-0.97). UCP2 -5331G>A is a regulatory SNP (rSNP), and its association with T2DM was significant among obese or abdominally obese subjects (P=0.017, OR=1.78, 95% CI=1.11-2.85; P=0.004, OR=1.82, 95% CI=1.21-2.74; respectively). UCP3 -2078C>T of UCP3 SNPs was associated with T2DM only among women (P=0.026, OR=0.71, 95% CI=0.52-0.96). Patients with combinations of the rSNPs UCP2 -5331G>A and UCP3 -2078C>T displayed an increased risk for T2DM. Specifically, those patients homozygous for both rSNPs among susceptible alleles had a higher risk for T2DM than patients heterozygous for one rSNP and homozygous for the other rSNP (P=0.033, OR=1.38, 95% CI=1.03-1.85). This association was more obvious in women (P=0.022, OR=1.58, 95% CI=1.07-2.34). CONCLUSIONS: Our results suggest that the UCP2 -5331G>A and UCP3 -2078C>T polymorphisms are susceptibility markers for T2DM among Koreans. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | 3' Flanking Region | en |
dc.subject | 5' Flanking Region | en |
dc.subject | Aged | en |
dc.subject | Diabetes Mellitus, Type 2/epidemiology/*genetics | en |
dc.subject | Exons/genetics | en |
dc.subject | Female | en |
dc.subject | Fluorescence Polarization Immunoassay | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Introns/genetics | en |
dc.subject | Ion Channels/*genetics | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Mitochondrial Proteins/*genetics | en |
dc.subject | Odds Ratio | en |
dc.subject | Phenotype | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.title | Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이혜자 | - |
dc.contributor.AlternativeAuthor | 류하정 | - |
dc.contributor.AlternativeAuthor | 신형두 | - |
dc.contributor.AlternativeAuthor | 박병래 | - |
dc.contributor.AlternativeAuthor | 김종열 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 송지현 | - |
dc.contributor.AlternativeAuthor | 오범석 | - |
dc.identifier.doi | 10.1016/j.cca.2008.07.029 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.