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Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus
Cited 36 time in
Web of Science
Cited 37 time in Scopus
- Authors
- Issue Date
- 2007-01-30
- Publisher
- American Diabetes Association
- Citation
- Diabetes Care. 2007 Feb;30(2):348-53.
- Keywords
- Adipose Tissue/*anatomy & histology ; Adult ; Blood Glucose/drug effects/metabolism ; Body Mass Index ; Diabetes, Gestational/*physiopathology ; Female ; Glucose Intolerance/*epidemiology ; Glucose Tolerance Test ; Hemoglobin A, Glycosylated/analysis ; Humans ; Insulin/blood/pharmacology ; Korea/epidemiology ; Pregnancy ; Risk Factors ; Viscera/anatomy & histology ; Body Composition
- Abstract
- OBJECTIVE: The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS: A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD(-) women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of +/-1.0 years and +/-1.0 kg/m(2), respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS: One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. beta-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS: High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM.
- ISSN
- 0149-5992 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17259506
https://hdl.handle.net/10371/46671
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