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Long-term follow up of Helicobacter pylori IgG serology after eradication and reinfection rate of H. pylori in South Korea

Cited 21 time in Web of Science Cited 25 time in Scopus
Authors
Lee, Jung Hoon; Kim, Nayoung; Chung, Jae Il; Kang, Kyung Phil; Lee, Sang Hyup; Park, Young Soo; Hwang, Jin-Hyeok; Kim, Jin-Wook; Jeong, Sook-Hyang; Lee, Dong Ho; Jung, Hyun Chae; Song, In Sung
Issue Date
2008-07-31
Publisher
Wiley-Blackwell
Citation
Helicobacter. 2008 Aug;13(4):288-94.
Keywords
AgedAnti-Bacterial Agents/therapeutic useAntibodies, Bacterial/*bloodDrug Therapy, CombinationFemaleFollow-Up StudiesGastritis, Atrophic/immunologyHelicobacter Infections/drug therapy/*immunology/microbiology/*prevention & controlHelicobacter pylori/*immunology/isolation & purificationHumansImmunoglobulin G/*bloodIntestinal Neoplasms/immunologyKoreaMaleMiddle AgedRecurrence/prevention & controlTime FactorsTreatment Outcome
Abstract
BACKGROUND: Serology is widely used for epidemiologic research of Helicobacter pylori. However, there is limited information on the long-term follow up of H. pylori titers after eradication. In addition, it is presumed that the reinfection rate decreases as the H. pylori infection rate decreases. The aim of this study was to investigate the long-term follow up of H. pylori IgG, and to evaluate the reinfection rate of H. pylori in Korea. METHODS: Among 247 patients, who were enrolled during 2003-07, 185 patients with invasive H. pylori test positive received proton pump inhibitor-based triple therapy, and follow-up H. pylori testing, including histology, CLOtest, culture, and serology, were evaluated 2, 10, and 18 months after H. pylori eradication. RESULTS: The initial H. pylori IgG optical density (OD(450 nm)), 2.06, gradually decreased to 0.63 (67% reduction) at 18 months after H. pylori eradication. The seroreversion rate was 5, 10, and 45% at 2, 10, and 18 months after H. pylori eradication, respectively. The recrudescence of H. pylori was 3.49%, and the annual reinfection rate was 2.94% per year. H. pylori IgG titers abruptly increased in cases with recrudescence and reinfection, and correlated with the results of the invasive H. pylori tests. CONCLUSION: The results of this study showed that H. pylori IgG serology could be used for the determination of reinfection of H. pylori, but not for the diagnosis of H. pylori eradication. The reinfection rate of H. pylori, in Korea, was found to be very low, 2.94% per year.
ISSN
1523-5378 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18665939

http://hdl.handle.net/10371/46687
DOI
https://doi.org/10.1111/j.1523-5378.2008.00616.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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